Epigenetic regulation of autophagy by the methyltransferase EZH2 through   an MTOR-dependent pathway

doi:10.1080/15548627.2015.1117734

CORC > 北京大学 > 生命科学学院

	Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway
	Wei, Fu-Zheng ; Cao, Ziyang ; Wang, Xi ; Wang, Hui ; Cai, Mu-Yan ; Li, Tingting ; Hattori, Naoko ; Wang, Donglai ; Du, Yipeng ; Song, Boyan ; Cao, Lin-Lin ; Shen, Changchun ; Wang, Lina ; Wang, Haiying ; Yang, Yang ; Xie, Dan ; Wang, Fan ; Ushijima, Toshikazu ; Zhao, Ying ; Zhu, Wei-Guo
刊名	AUTOPHAGY
	2015
关键词	autophagy EZH2 histone modification MTA2 MTOR pathway EMBRYONIC STEM-CELLS CHROMATIN-REMODELING COMPLEX HISTONE DEACETYLASE DNA-DAMAGE MI-2/NURD COMPLEX TUMOR-SUPPRESSOR FACTOR CHD4 IN-VIVO NURD METHYLATION
DOI	10.1080/15548627.2015.1117734
英文摘要	Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of proteins and organelles. Although the autophagy regulation machinery has been widely studied, the key epigenetic control of autophagy process still remains unknown. Here we report that the methyltransferase EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) epigenetically represses several negative regulators of the MTOR (mechanistic target of rapamycin [serine/threonine kinase]) pathway, such as TSC2, RHOA, DEPTOR, FKBP11, RGS16 and GPI. EZH2 was recruited to these genes promoters via MTA2 (metastasis associated 1 family, member 2), a component of the nucleosome remodeling and histone deacetylase (NuRD) complex. MTA2 was identified as a new chromatin binding protein whose association with chromatin facilitated the subsequent recruitment of EZH2 to silenced targeted genes, especially TSC2. Downregulation of TSC2 (tuberous sclerosis 2) by EZH2 elicited MTOR activation, which in turn modulated subsequent MTOR pathway-related events, including inhibition of autophagy. In human colorectal carcinoma (CRC) tissues, the expression of MTA2 and EZH2 correlated negatively with expression of TSC2, which reveals a novel link among epigenetic regulation, the MTOR pathway, autophagy induction, and tumorigenesis.; 973 Projects [2011CB910100, 2011CB504200, 2013CB911000]; National Natural Science Foundation of China [81222028, 81321003, 81472581, 81530074, 31570812, 91319302]; Ministry of Science and Technology of China [B70001]; SCI(E); PubMed; ARTICLE; zhaoying0812@bjmu.edu.cn; zhuweiguo@bjmu.edu.cn; 12; 2309-2322; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435481]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wei, Fu-Zheng,Cao, Ziyang,Wang, Xi,et al. Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway[J]. AUTOPHAGY,2015.
APA	Wei, Fu-Zheng.,Cao, Ziyang.,Wang, Xi.,Wang, Hui.,Cai, Mu-Yan.,...&Zhu, Wei-Guo.(2015).Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway.AUTOPHAGY.
MLA	Wei, Fu-Zheng,et al."Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway".AUTOPHAGY (2015).