CSGene: a literature-based database for cell senescence genes and its   application to identify critical cell aging pathways and associated   diseases

doi:10.1038/cddis.2015.414

CORC > 北京大学 > 生命科学学院

	CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases
	Zhao, M. ; Chen, L. ; Qu, H.
刊名	CELL DEATH & DISEASE
	2016
关键词	RATE-LIMITING ENZYMES METABOLIC PATHWAYS WEB RESOURCE E. COLI CANCER KNOWLEDGEBASE ONTOLOGY GENOME MOUSE KEGG
DOI	10.1038/cddis.2015.414
英文摘要	Cell senescence is a cellular process in which normal diploid cells cease to replicate and is a major driving force for human cancers and aging-associated diseases. Recent studies on cell senescence have identified many new genetic components and pathways that control cell aging. However, there is no comprehensive resource for cell senescence that integrates various genetic studies and relationships with cell senescence, and the risk associated with complex diseases such as cancer is still unexplored. We have developed the first literature-based gene resource for exploring cell senescence genes, CSGene. We complied 504 experimentally verified genes from public data resources and published literature. Pathway analyses highlighted the prominent roles of cell senescence genes in the control of rRNA gene transcription and unusual rDNA repeat that constitute a center for the stability of the whole genome. We also found a strong association of cell senescence with HIV-1 infection and viral carcinogenesis that are mainly related to promoter/enhancer binding and chromatin modification processes. Moreover, pan-cancer mutation and network analysis also identified common cell aging mechanisms in cancers and uncovered a highly modular network structure. These results highlight the utility of CSGene for elucidating the complex cellular events of cell senescence.; National Natural Science Foundation of China [31171270]; university of sunshine coast; SCI(E); PubMed; ARTICLE; quh@mail.cbi.pku.edu.cn; e2053; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435369]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao, M.,Chen, L.,Qu, H.. CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases[J]. CELL DEATH & DISEASE,2016.
APA	Zhao, M.,Chen, L.,&Qu, H..(2016).CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases.CELL DEATH & DISEASE.
MLA	Zhao, M.,et al."CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases".CELL DEATH & DISEASE (2016).