Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice

doi:10.1523/JNEUROSCI.2528-15.2016

CORC > 北京大学 > 生命科学学院

	Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice
	Zhang, Qiangge ; Gao, Xian ; Li, Chenchen ; Feliciano, Catia ; Wang, Dongqing ; Zhou, Dingxi ; Mei, Yuan ; Monteiro, Patricia ; Anand, Michelle ; Itohara, Shigeyoshi ; Dong, Xiaowei ; Fu, Zhanyan ; Feng, Guoping
刊名	JOURNAL OF NEUROSCIENCE
	2016
关键词	dendrites dentate gyrus intellectual disability learning and memory nArgBP2 Sorbs2 MESSENGER-RNA EXPRESSION ACTIN CYTOSKELETON STRUCTURAL PLASTICITY ADAPTER PROTEIN DENTATE GYRUS ESTROUS-CYCLE STRESS FIBERS ALPHA-ACTININ MUTANT MICE HIPPOCAMPUS
DOI	10.1523/JNEUROSCI.2528-15.2016
英文摘要	Intellectual disability is a common neurodevelopmental disorder characterized by impaired intellectual and adaptive functioning. Both environmental insults and genetic defects contribute to the etiology of intellectual disability. Copy number variations of SORBS2 have been linked to intellectual disability. However, the neurobiological function of SORBS2 in the brain is unknown. The SORBS2 gene encodes ArgBP2 (Arg/c-Abl kinase binding protein 2) protein in non-neuronal tissues and is alternatively spliced in the brain to encode nArgBP2 protein. Wefound nArgBP2 colocalized with F-actin at dendritic spines and growth cones in cultured hippocampal neurons. In the mouse brain, nArgBP2 was highly expressed in the cortex, amygdala, and hippocampus, and enriched in the outer one-third of the molecular layer in dentate gyrus. Genetic deletion of Sorbs2 in mice led to reduced dendritic complexity and decreased frequency of AMPAR-miniature spontaneous EPSCs in dentate gyrus granule cells. Behavioral characterization revealed that Sorbs2 deletion led to a reduced acoustic startle response, and defective long-term object recognition memory and contextual fear memory. Together, our findings demonstrate, for the first time, an important role for nArgBP2 in neuronal dendritic development and excitatory synaptic transmission, which may thus inform exploration of neurobiological basis of SORBS2 deficiency in intellectual disability.; Poitras Center for Affective Disorders at Massachusetts Institute of Technology; Stanley Center for Psychiatric Research at Broad Institute of Massachusetts Institute of Technology; Harvard, Duke Institute for Brain Sciences; National Institutes of Health/National Institute of Mental Health [R01MH081201]; Stanley Center for Psychiatric Research at Broad Institute of Massachusetts, Institute of Technology, Harvard; China Scholarship Council; National Science Foundation Graduate Fellowship; Integrative Neuronal Systems; Stanley Center for Psychiatric Research at the Broad Institute of Massachusetts Institute of Technology, Harvard; Portuguese Foundation for Science and Technology doctoral fellowship [SFRH/BD/33894/2009]; Stanley Center for Psychiatric Research at Broad Institute of Massachusetts Institute of Technology, Harvard; Brain and Behavior Research Foundation National Institute of Mental Health Young Investigator Grant; SCI(E); PubMed; ARTICLE; fengg@mit.edu; 7; 2247-2260; 36
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434851]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Qiangge,Gao, Xian,Li, Chenchen,et al. Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice[J]. JOURNAL OF NEUROSCIENCE,2016.
APA	Zhang, Qiangge.,Gao, Xian.,Li, Chenchen.,Feliciano, Catia.,Wang, Dongqing.,...&Feng, Guoping.(2016).Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.JOURNAL OF NEUROSCIENCE.
MLA	Zhang, Qiangge,et al."Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice".JOURNAL OF NEUROSCIENCE (2016).