Importin-7 mediates memory consolidation through regulation of nuclear   translocation of training-activated MAPK in Drosophila

doi:10.1073/pnas.1520401113

CORC > 北京大学 > 生命科学学院

	Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila
	Li, Qian ; Zhang, Xuchen ; Hu, Wantong ; Liang, Xitong ; Zhang, Fang ; Wang, Lianzhang ; Liu, Zhong-Jian ; Zhong, Yi
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2016
关键词	long-term memory consolidation Drosophila importin MAPK LONG-TERM-MEMORY SYNAPTIC PLASTICITY MUSHROOM BODY GENE-EXPRESSION NMDA RECEPTOR NEURONS ERK TRANSPORT MOLESKIN BIOLOGY
DOI	10.1073/pnas.1520401113
英文摘要	Translocation of signaling molecules, MAPK in particular, from the cytosol to nucleus represents a universal key element in initiating the gene program that determines memory consolidation. Translocation mechanisms and their behavioral impact, however, remain to be determined. Here, we report that a highly conserved nuclear transporter, Drosophila importin-7 (DIM-7), regulates import of training-activated MAPK for consolidation of long-term memory (LTM). We show that silencing DIM-7 functions results in impaired LTM, whereas overexpression of DIM-7 enhances LTM. This DIM-7-dependent regulation of LTM is confined to a consolidation time window and in mushroom body neurons. Image data show that bidirectional alteration in DIM-7 expression results in proportional changes in the intensity of training-activated MAPK accumulated within the nuclei of mushroom body neurons during LTM consolidation. Such DIM-7-regulated nuclear accumulation of activated MAPK is observed only in the training specified for LTM induction and determines the amplitude, but not the time course, of memory consolidation.; National Science Foundation of China [91332207]; National Basic Research Project (973 Program) of the Ministry of Science and Technology of China [2013cb835100]; Tsinghua University Initiative Scientific Research Program [20111080956]; Tsinghua-Peking Joint Center for Life Sciences; SCI(E); PubMed; ARTICLE; zhongyi@tsinghua.edu.cn; 11; 3072-3077; 113
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434683]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Qian,Zhang, Xuchen,Hu, Wantong,et al. Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016.
APA	Li, Qian.,Zhang, Xuchen.,Hu, Wantong.,Liang, Xitong.,Zhang, Fang.,...&Zhong, Yi.(2016).Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
MLA	Li, Qian,et al."Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016).