Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production   in Endothelial Cells

doi:10.1155/2016/2193210

CORC > 北京大学 > 生命科学学院

	Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells
	Xia, Weiwei ; Zhang, Aihua ; Jia, Zhanjun ; Gu, Jun ; Chen, Hongbing
刊名	MEDIATORS OF INFLAMMATION
	2016
关键词	CORONARY-HEART-DISEASE CARDIOVASCULAR-DISEASE INFLAMMATION INTERLEUKIN-6 ATHEROSCLEROSIS EXPRESSION PATHWAY RISK GENE MICE
DOI	10.1155/2016/2193210
英文摘要	Both statins and klotho have been shown to be beneficial in vascular diseases. Interleukin- (IL-) 6 is evidenced as an indicator reflecting the stability of atherosclerotic plaque and involved in the pathogenesis of artery atherosclerosis. However, the relationship between statin, klotho, and IL-6 under an inflammatory environment is unknown. Using primary human umbilical vein endothelial cells (HUVECs), pravastatin dose-dependently induced klotho expression in contrast to remarkable suppression to IL-6 expressions determined by qRT-PCR. Moreover, TNF-alpha-induced IL-6 was partly but significantly blunted by pravastatin detected by ELISA. To further study the role of klotho in modulating IL-6 expression, endothelial cells with klotho overexpression were treated with TNF-alpha. Importantly, TNF-alpha-induced IL-6 production was markedly attenuated in klotho-overexpressed cells. In agreement with in vitro data, a marked reduction of klotho mRNA expression was found in isolated peripheral blood mononuclear cells (PBMCs) from patients with atherosclerosis. Together, these data suggested that pravastatin could suppress IL-6 production via promoting klotho expression in endothelial cells under inflammatory stimuli.; Nanjing Medical University [2015NJMUZD053]; Nanjing Children Hospital [ETYY2013025]; National Natural Science Foundation of China [81370802]; SCI(E); PubMed; ARTICLE; jiazj72@hotmail.com; gj@pku.edu.cn; chenghb1999@126.com; 2193210; 2016
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434291]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xia, Weiwei,Zhang, Aihua,Jia, Zhanjun,et al. Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells[J]. MEDIATORS OF INFLAMMATION,2016.
APA	Xia, Weiwei,Zhang, Aihua,Jia, Zhanjun,Gu, Jun,&Chen, Hongbing.(2016).Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells.MEDIATORS OF INFLAMMATION.
MLA	Xia, Weiwei,et al."Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells".MEDIATORS OF INFLAMMATION (2016).