DELLA-mediated PIF degradation contributes to coordination of light and   gibberellin signalling in Arabidopsis

doi:10.1038/ncomms11868

CORC > 北京大学 > 生命科学学院

	DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis
	Li, Kunlun ; Yu, Renbo ; Fan, Liu-Min ; Wei, Ning ; Chen, Haodong ; Deng, Xing Wang
刊名	NATURE COMMUNICATIONS
	2016
关键词	PHYTOCHROME-INTERACTING FACTORS E3 UBIQUITIN LIGASE NEGATIVE REGULATOR TRANSCRIPTION FACTORS SEED-GERMINATION CELL ELONGATION ROOT-GROWTH RESPONSES PROTEIN PHOTOMORPHOGENESIS
DOI	10.1038/ncomms11868
英文摘要	Light and gibberellins (GAs) antagonistically regulate hypocotyl elongation in plants. It has been demonstrated that DELLAs, which are negative regulators of GA signalling, inhibit phytochrome-interacting factors 3 and 4 (PIF3 and PIF4) by sequestering their DNA-recognition domains. However, it is unclear whether there are other mechanisms of regulatory crosstalk between DELLAs and PIFs. Here, we demonstrate that DELLAs negatively regulate the abundance of four PIF proteins through the ubiquitin-proteasome system. Reduction of PIF3 protein abundance by DELLAs correlates closely with reduced hypocotyl elongation. Both sequestration and degradation of PIF3 by DELLAs contribute to a reduction in PIF3 binding to its target genes. Thus, we show that promotion of PIF degradation by DELLAs is required to coordinate light and GA signals, and the dual regulation of transcription factors by DELLAs by both sequestration and degradation may be a general mechanism.; National Natural Science Foundation of China [31330048, 31271294]; National Program on Key Basic Research Project of China [2012CB910900]; NIH of United States [GM-47850]; Peking-Tsinghua Center for Life Sciences; State Key Laboratory of Protein and Plant Gene Research; SCI(E); PubMed; ARTICLE; chenhaodong@pku.edu.cn; deng@pku.edu.cn; 11868; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433399]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Kunlun,Yu, Renbo,Fan, Liu-Min,et al. DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis[J]. NATURE COMMUNICATIONS,2016.
APA	Li, Kunlun,Yu, Renbo,Fan, Liu-Min,Wei, Ning,Chen, Haodong,&Deng, Xing Wang.(2016).DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis.NATURE COMMUNICATIONS.
MLA	Li, Kunlun,et al."DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis".NATURE COMMUNICATIONS (2016).