Stuxnet Facilitates the Degradation of Polycomb Protein during   Development

doi:10.1016/j.devcel.2016.05.013

CORC > 北京大学 > 生命科学学院

	Stuxnet Facilitates the Degradation of Polycomb Protein during Development
	Du, Juan ; Zhang, Junzheng ; He, Tao ; Li, Yajuan ; Su, Ying ; Tie, Feng ; Liu, Min ; Harte, Peter J. ; Zhu, Alan Jian
刊名	DEVELOPMENTAL CELL
	2016
关键词	UBIQUITIN-LIKE DOMAIN TUMOR-SUPPRESSOR ACTIVITY TRITHORAX GROUP PROTEINS DROSOPHILA-MELANOGASTER BITHORAX COMPLEX GROUP GENES HISTONE H3 CHROMATIN IDENTIFICATION TRANSCRIPTION
DOI	10.1016/j.devcel.2016.05.013
英文摘要	Polycomb-group (PcG) proteins function to ensure correct deployment of developmental programs by epigenetically repressing target gene expression. Despite the importance, few studies have been focused on the regulation of PcG activity itself. Here, we report a Drosophila gene, stuxnet (stx), that controls Pc protein stability. We find that heightened stx activity leads to homeotic transformation, reduced Pc activity, and de-repression of PcG targets. Conversely, stx mutants, which can be rescued by decreased Pc expression, display developmental defects resembling hyperactivation of Pc. Our biochemical analyses provide a mechanistic basis for the interaction between stx and Pc; Stx facilitates Pc degradation in the proteasome, independent of ubiquitin modification. Furthermore, this mode of regulation is conserved in vertebrates. Mouse stx promotes degradation of Cbx4, an orthologous Pc protein, in vertebrate cells and induces homeotic transformation in Drosophila. Our results highlight an evolutionarily conserved mechanism of regulated protein degradation on PcG homeostasis and epigenetic activity.; Ministry of Sciences and Technology of China [2014CB942804]; National Natural Science Foundation of China [31371410, 31401241, 31471382]; NIH [R01GM39255, R01GM085175]; Peking-Tsinghua Center for Life Sciences and State Key Laboratory of Membrane Biology; SCI(E); PubMed; ARTICLE; zhua@pku.edu.cn; 6; 507-519; 37
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433243]
专题	生命科学学院
推荐引用方式 GB/T 7714	Du, Juan,Zhang, Junzheng,He, Tao,et al. Stuxnet Facilitates the Degradation of Polycomb Protein during Development[J]. DEVELOPMENTAL CELL,2016.
APA	Du, Juan.,Zhang, Junzheng.,He, Tao.,Li, Yajuan.,Su, Ying.,...&Zhu, Alan Jian.(2016).Stuxnet Facilitates the Degradation of Polycomb Protein during Development.DEVELOPMENTAL CELL.
MLA	Du, Juan,et al."Stuxnet Facilitates the Degradation of Polycomb Protein during Development".DEVELOPMENTAL CELL (2016).