Role of Hippocampal beta-Adrenergic and Glucocorticoid Receptors in the   Novelty-Induced Enhancement of Fear Extinction

doi:10.1523/JNEUROSCI.0005-15.2015

CORC > 北京大学 > 生命科学学院

	Role of Hippocampal beta-Adrenergic and Glucocorticoid Receptors in the Novelty-Induced Enhancement of Fear Extinction
	Liu, Jian-Feng ; Yang, Chang ; Deng, Jia-Hui ; Yan, Wei ; Wang, Hui-Min ; Luo, Yi-Xiao ; Shi, Hai-Shui ; Meng, Shi-Qiu ; Chai, Bai-Sheng ; Fang, Qin ; Chai, Ning ; Xue, Yan-Xue ; Sun, Jia ; Chen, Chen ; Wang, Xue-Yi ; Wang, Ji-Shi ; Lu, Lin
刊名	JOURNAL OF NEUROSCIENCE
	2015
关键词	beta-adrenergic receptors behavioral tag extinction glucocorticoid receptors hippocampus LONG-TERM POTENTIATION RAT DENTATE GYRUS REQUIRES PROTEIN-SYNTHESIS ONE-TRIAL AVOIDANCE MEMORY CONSOLIDATION NORADRENERGIC ACTIVATION BASOLATERAL AMYGDALA NEUROTROPHIC FACTOR CONDITIONED FEAR SPATIAL NOVELTY
DOI	10.1523/JNEUROSCI.0005-15.2015
英文摘要	Fear extinction forms a new memory but does not erase the original fear memory. Exposure to novelty facilitates transfer of short-term extinction memory to long-lasting memory. However, the underlying cellular and molecular mechanisms are still unclear. Using a classical contextual fear-conditioning model, we investigated the effect of novelty on long-lasting extinction memory in rats. We found that exposure to a novel environment but not familiar environment 1 h before or after extinction enhanced extinction long-term memory (LTM) and reduced fear reinstatement. However, exploring novelty 6 h before or after extinction had no such effect. Infusion of the beta-adrenergic receptor (beta AR) inhibitor propranolol and glucocorticoid receptor (GR) inhibitor RU486 into the CA1 area of the dorsal hippocampus before novelty exposure blocked the effect of novelty on extinction memory. Propranolol prevented activation of the hippocampal PKA-CREB pathway, and RU486 prevented activation of the hippocampal extracellular signal-regulated kinase 1/2 (Erk1/2)-CREB pathway induced by novelty exposure. These results indicate that the hippocampal beta AR-PKA-CREB and GR-Erk1/2-CREB pathways mediate the extinction-enhancing effect of novelty exposure. Infusion of RU486 or the Erk1/2 inhibitor U0126, but not propranolol or the PKA inhibitor Rp-cAMPS, into the CA1 before extinction disrupted the formation of extinction LTM, suggesting that hippocampal GR and Erk1/2 but not beta AR or PKA play critical roles in this process. These results indicate that novelty promotes extinction memory via hippocampal beta AR- and GR-dependent pathways, and Erk1/2 may serve as a behavioral tag of extinction.; National Basic Research Program of China [2015CB856400, 2015CB553503]; Natural Science Foundation of China [31230033, 91432303, 81221002]; SCI(E); PubMed; SSCI; ARTICLE; jswang_yg@yahoo.com; linlu@bjmu.edu.cn; 21; 8308-8321; 35
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/419841]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Liu, Jian-Feng,Yang, Chang,Deng, Jia-Hui,et al. Role of Hippocampal beta-Adrenergic and Glucocorticoid Receptors in the Novelty-Induced Enhancement of Fear Extinction[J]. JOURNAL OF NEUROSCIENCE,2015.
APA	Liu, Jian-Feng.,Yang, Chang.,Deng, Jia-Hui.,Yan, Wei.,Wang, Hui-Min.,...&Lu, Lin.(2015).Role of Hippocampal beta-Adrenergic and Glucocorticoid Receptors in the Novelty-Induced Enhancement of Fear Extinction.JOURNAL OF NEUROSCIENCE.
MLA	Liu, Jian-Feng,et al."Role of Hippocampal beta-Adrenergic and Glucocorticoid Receptors in the Novelty-Induced Enhancement of Fear Extinction".JOURNAL OF NEUROSCIENCE (2015).