Emergence, Retention and Selection: A Trilogy of Origination for   Functional De Novo Proteins from Ancestral LncRNAs in Primates

doi:10.1371/journal.pgen.1005391

CORC > 北京大学 > 生命科学学院

	Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates
	Chen, Jia-Yu ; Shen, Qing Sunny ; Zhou, Wei-Zhen ; Peng, Jiguang ; He, Bin Z. ; Li, Yumei ; Liu, Chu-Jun ; Luan, Xuke ; Ding, Wanqiu ; Li, Shuxian ; Chen, Chunyan ; Tan, Bertrand Chin-Ming ; Zhang, Yong E. ; He, Aibin ; Li, Chuan-Yun
刊名	PLOS GENETICS
	2015
关键词	RHESUS MACAQUE GC-CONTENT DROSOPHILA-MELANOGASTER PEPTIDEATLAS PROJECT NONCODING RNAS HUMAN PROTEOME ORPHAN GENES EVOLUTION GENOME EXPRESSION
DOI	10.1371/journal.pgen.1005391
英文摘要	While some human-specific protein-coding genes have been proposed to originate from ancestral lncRNAs, the transition process remains poorly understood. Here we identified 64 hominoid-specific de novo genes and report a mechanism for the origination of functional de novo proteins from ancestral lncRNAs with precise splicing structures and specific tissue expression profiles. Whole-genome sequencing of dozens of rhesus macaque animals revealed that these lncRNAs are generally not more selectively constrained than other lncRNA loci. The existence of these newly-originated de novo proteins is also not beyond anticipation under neutral expectation, as they generally have longer theoretical lifespan than their current age, due to their GC-rich sequence property enabling stable ORFs with lower chance of non-sense mutations. Interestingly, although the emergence and retention of these de novo genes are likely driven by neutral forces, population genetics study in 67 human individuals and 82 macaque animals revealed signatures of purifying selection on these genes specifically in human population, indicating a proportion of these newly-originated proteins are already functional in human. We thus propose a mechanism for creation of functional de novo proteins from ancestral lncRNAs during the primate evolution, which may contribute to human-specific genetic novelties by taking advantage of existed genomic contexts.; National Key Basic Research Program of China [2013CB531202, 2012CB518004]; National Natural Science Foundation of China [31471240, 31171269, 31221002]; SCI(E); PubMed; ARTICLE; ahe@pku.edu.cn; chuanyunli@pku.edu.cn; 7; e1005391; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418646]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chen, Jia-Yu,Shen, Qing Sunny,Zhou, Wei-Zhen,et al. Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates[J]. PLOS GENETICS,2015.
APA	Chen, Jia-Yu.,Shen, Qing Sunny.,Zhou, Wei-Zhen.,Peng, Jiguang.,He, Bin Z..,...&Li, Chuan-Yun.(2015).Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates.PLOS GENETICS.
MLA	Chen, Jia-Yu,et al."Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates".PLOS GENETICS (2015).