Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is   Significantly Associated with Reduced Mortality at Advanced Ages

doi:10.1089/rej.2015.1737

CORC > 北京大学 > 生命科学学院

	Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages
	Zeng, Yi ; Chen, Huashuai ; Ni, Ting ; Ruan, Rongping ; Nie, Chao ; Liu, Xiaomin ; Feng, Lei ; Zhang, Fengyu ; Lu, Jiehua ; Li, Jianxin ; Li, Yang ; Tao, Wei ; Gregory, Simon G. ; Gottschalk, William ; Lutz, Michael W. ; Land, Kenneth C. ; Yashin, Anatoli ; Tan, Qihua ; Yang, Ze ; Bolund, Lars ; Ming, Qi ; Yang, Huanming ; Min, Junxia ; Willcox, D. Craig ; Willcox, Bradley J. ; Gu, Jun ; Hauser, Elizabeth ; Tian, Xiao-Li ; Vaupel, James W.
刊名	REJUVENATION RESEARCH
	2016
关键词	OLDEST-OLD CHINESE COGNITIVE FUNCTION FOXO GENOTYPES CONSUMPTION LONGEVITY DEPRESSION CANCER GREEN
DOI	10.1089/rej.2015.1737
英文摘要	On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that interactions between carrying FOXO1A-209 genotypes and tea drinking are significantly associated with lower risk of mortality at advanced ages. Such a significant association is replicated in two independent Han Chinese CLHLS cohorts (p = 0.028-0.048 in the discovery and replication cohorts, and p = 0.003-0.016 in the combined dataset). We found the associations between tea drinking and reduced mortality are much stronger among carriers of the FOXO1A-209 genotype compared to non-carriers, and drinking tea is associated with a reversal of the negative effects of carrying FOXO1A-209 minor alleles, that is, from a substantially increased mortality risk to substantially reduced mortality risk at advanced ages. The impacts are considerably stronger among those who carry two copies of the FOXO1A minor allele than those who carry one copy. On the basis of previously reported experiments on human cell models concerning FOXO1A-by-tea-compounds interactions, we speculate that results in the present study indicate that tea drinking may inhibit FOXO1A-209 gene expression and its biological functions, which reduces the negative impacts of FOXO1A-209 gene on longevity (as reported in the literature) and offers protection against mortality risk at oldest-old ages. Our empirical findings imply that the health outcomes of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles, and the research on the effects of nutrigenomics interactions could potentially be useful for rejuvenation therapies in the clinic or associated healthy aging intervention programs.; National Natural Science Foundation of China [71110107025, 71233001, 71490732]; National Key Basic Research Program of China [2013CB530700]; NIA/NIH [R01 AG023627]; National Institutes of Health (NIH) Pepper Center [P30AG028716]; National Insitute on Aging (NIA)/NIH [R01AG027060, R01AG038707]; SCI(E); PubMed; ARTICLE; zengyi@duke.edu; tianxiaoli@pku.edu.cn; 3; 195-203; 19
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/417842]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zeng, Yi,Chen, Huashuai,Ni, Ting,et al. Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages[J]. REJUVENATION RESEARCH,2016.
APA	Zeng, Yi.,Chen, Huashuai.,Ni, Ting.,Ruan, Rongping.,Nie, Chao.,...&Vaupel, James W..(2016).Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.REJUVENATION RESEARCH.
MLA	Zeng, Yi,et al."Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages".REJUVENATION RESEARCH (2016).