Heterochromatin remodeling by CDK12 contributes to learning in   Drosophila

doi:10.1073/pnas.1502943112

CORC > 北京大学 > 生命科学学院

	Heterochromatin remodeling by CDK12 contributes to learning in Drosophila
	Pan, Lixia ; Xie, Wenbing ; Li, Kai-Le ; Yang, Zhihao ; Xu, Jiang ; Zhang, Wenhao ; Liu, Lu-Ping ; Ren, Xingjie ; He, Zhimin ; Wu, Junyu ; Sun, Jin ; Wei, Hui-Min ; Wang, Daliang ; Xie, Wei ; Li, Wei ; Ni, Jian-Quan ; Sun, Fang-Lin
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2015
关键词	epigenetic transition HP1 RNAPII C-terminal domain kinase histone H3 on Lys9 methylation neuronal function RNA-POLYMERASE-II HISTONE H3 PROTEIN-KINASE HP1 BINDING LYSINE 9 TRANSCRIPTION MELANOGASTER CHROMATIN PHOSPHORYLATION EXPRESSION
DOI	10.1073/pnas.1502943112
英文摘要	Dynamic regulation of chromatin structure is required to modulate the transcription of genes in eukaryotes. However, the factors that contribute to the plasticity of heterochromatin structure are elusive. Here, we report that cyclin-dependent kinase 12 (CDK12), a transcription elongation-associated RNA polymerase II (RNAPII) kinase, antagonizes heterochromatin enrichment in Drosophila chromosomes. Notably, loss of CDK12 induces the ectopic accumulation of heterochromatin protein 1 (HP1) on euchromatic arms, with a prominent enrichment on the X chromosome. Furthermore, ChIP and sequencing analysis reveals that the heterochromatin enrichment on the X chromosome mainly occurs within long genes involved in neuronal functions. Consequently, heterochromatin enrichment reduces the transcription of neuronal genes in the adult brain and results in a defect in Drosophila courtship learning. Taken together, these results define a previously unidentified role of CDK12 in controlling the epigenetic transition between euchromatin and heterochromatin and suggest a chromatin regulatory mechanism in neuronal behaviors.; Ministry of Science and Technology of the People's Republic of China [2011CB965300, 2013CB835100, 2013CB35102, 2015BA1091303]; National Natural Science Foundation of China [31330043, 31371496, 31371489, 91419304]; Projects of the Science and Technology Program of Yunnan Province [2013GA003]; Shanghai Pujiang Program [13PJ1408100]; 1000 Talents Youth Program; Tsinghua-Peking Center for Life Sciences; SCI(E); PubMed; ARTICLE; nijq@tsinghua.edu.cn; flsun@mail.tsinghua.edu.cn; 45; 13988-13993; 112
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/417219]
专题	生命科学学院
推荐引用方式 GB/T 7714	Pan, Lixia,Xie, Wenbing,Li, Kai-Le,et al. Heterochromatin remodeling by CDK12 contributes to learning in Drosophila[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2015.
APA	Pan, Lixia.,Xie, Wenbing.,Li, Kai-Le.,Yang, Zhihao.,Xu, Jiang.,...&Sun, Fang-Lin.(2015).Heterochromatin remodeling by CDK12 contributes to learning in Drosophila.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
MLA	Pan, Lixia,et al."Heterochromatin remodeling by CDK12 contributes to learning in Drosophila".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015).