A2BP1 gene polymorphisms association with olanzapine-induced weight gain

doi:10.1016/j.phrs.2015.06.003

CORC > 北京大学 > 生命科学学院

	A2BP1 gene polymorphisms association with olanzapine-induced weight gain
	Dong, Licai ; Yan, Hao ; Huang, Xuebing ; Hu, Xiaofeng ; Yang, Yongfeng ; Ma, Cuicui ; Du, Bo ; Lu, Tianlan ; Jin, Chao ; Wang, Lifang ; Yu, Hao ; Dong, Zheng ; Li, Wenqiang ; Ruan, Yanyan ; Zhang, Hongyan ; Zhang, Hongxing ; Mi, Weifeng ; Ma, Wenbin ; Li, Keqing ; Lv, Luxian ; Zhang, Dai ; Yue, Weihua
刊名	PHARMACOLOGICAL RESEARCH
	2015
关键词	Schizophrenia Ataxin-2 binding protein 1 Olanzapine Antipsychotic induced weight gain RECEPTOR GENE PIMA-INDIANS SCHIZOPHRENIA OBESITY BRAIN EXPRESSION VARIANTS ATAXIN-2 LINKAGE PROTEIN
DOI	10.1016/j.phrs.2015.06.003
英文摘要	The ataxin-2 binding protein 1 (A2BP1)gene is reported to be one of the susceptibility genes in schizophrenia, autism, and obesity. The aim of this study was to explore the association of A2BP1 gene polymorphisms with antipsychotic induced weight gain (AIWG) in Chinese Han population. Three hundred and twenty-eight patients with schizophrenia were followed-up for an 8-week period of treatment with olanzapine. The fasting weights of 328 patients were measured before and after the 8-week course of treatment. Four single nucleotide polymorphisms (SNPs: rs8048076, rs1478697, rs10500331, and rs4786847) of the A2BP1 gene were genotyped by polymerase chain reaction (PCR). We analyzed putative association of A2BP1 polymorphisms with AIWG of olanzapine using linear regression analysis and found that SNP rs1478697 was significantly associated with AIWG caused by olanzapine (p = 0.0012; Bonferroni corrected p = 0.0048). The association was replicated in another independent sample including 208 first-episode and drug-naive patients presenting with schizophrenia after a 4-week treatment with olanzapine (p = 0.0092; Bonferroni corrected p = 0.0368; meta p = 5.33 x 10(-5)). To explore the biological plausibility of A2BP1 in the pathogenesis of AIWG, we made expression analyses and eQTL analyses; these analyses showed that A2BP1 was highly expressed in whole brain tissues using the HBT database, and that rs1478697 has an expression quantitative trait locus effect in human cerebellar cortex tissues using the BRAINEAC database (p=2.50E-04). In conclusion, the rs1478697 in A2BP1 may be associated with AIWG induced by 8-week treatment with olanzapine. (C) 2015 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [81222017, 91232305]; Beijing Municipal Natural Science Foundation [7132182]; National Key Technology R&D Program of China [2015BAI13B01, 2012BAI01B06]; National High Technology Research and Development Program of China [2008AA02Z401]; SCI(E); PubMed; ARTICLE; diyue@bjmu.edu.cn; 155-161; 99
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/416647]
专题	生命科学学院
推荐引用方式 GB/T 7714	Dong, Licai,Yan, Hao,Huang, Xuebing,et al. A2BP1 gene polymorphisms association with olanzapine-induced weight gain[J]. PHARMACOLOGICAL RESEARCH,2015.
APA	Dong, Licai.,Yan, Hao.,Huang, Xuebing.,Hu, Xiaofeng.,Yang, Yongfeng.,...&Yue, Weihua.(2015).A2BP1 gene polymorphisms association with olanzapine-induced weight gain.PHARMACOLOGICAL RESEARCH.
MLA	Dong, Licai,et al."A2BP1 gene polymorphisms association with olanzapine-induced weight gain".PHARMACOLOGICAL RESEARCH (2015).