Ring finger protein 166 potentiates RNA virus-induced interferon-beta   production via enhancing the ubiquitination of TRAF3 and TRAF6

doi:10.1038/srep14770

CORC > 北京大学 > 生命科学学院

	Ring finger protein 166 potentiates RNA virus-induced interferon-beta production via enhancing the ubiquitination of TRAF3 and TRAF6
	Chen, Hai-Wei ; Yang, Yong-Kang ; Xu, Hao ; Yang, Wei-Wei ; Zhai, Zhong-He ; Chen, Dan-Ying
刊名	SCIENTIFIC REPORTS
	2015
关键词	CYCLIC GMP-AMP PSORIASIS SUSCEPTIBILITY GENE INNATE IMMUNE-RESPONSES NF-KAPPA-B RIG-I CYTOSOLIC DNA NEGATIVE REGULATOR ANTIVIRAL RESPONSE ADAPTER PROTEIN IFN-BETA
DOI	10.1038/srep14770
英文摘要	Host cells orchestrate the production of IFN-beta upon detecting invading viral pathogens. Here, we report that Ring finger protein 166 (RNF166) potentiates RNA virus-triggered IFN-beta production. Overexpression of RNF166 rather than its homologous proteins RNF114, RNF125, and RNF138, enhanced Sendai virus (SeV)-induced activation of the IFN-beta promoter. Knockdown of endogenous RNF166, but not other RNFs, inhibited the IFN-beta production induced by SeV and encephalomyocarditis virus. RNF166 interacted with TRAF3 and TRAF6. SeV-induced ubiquitination of TRAF3 and TRAF6 was suppressed when endogenous RNF166 rather than RNF114/138 was knocked down. These findings suggest that RNF166 positively regulates RNA virus-triggered IFN-beta production by enhancing the ubiquitination of TRAF3 and TRAF6.; National Natural Science Foundation of China [31170822, 31470841]; SCI(E); PubMed; ARTICLE; dychen@pku.edu.cn; 14770; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/415767]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chen, Hai-Wei,Yang, Yong-Kang,Xu, Hao,et al. Ring finger protein 166 potentiates RNA virus-induced interferon-beta production via enhancing the ubiquitination of TRAF3 and TRAF6[J]. SCIENTIFIC REPORTS,2015.
APA	Chen, Hai-Wei,Yang, Yong-Kang,Xu, Hao,Yang, Wei-Wei,Zhai, Zhong-He,&Chen, Dan-Ying.(2015).Ring finger protein 166 potentiates RNA virus-induced interferon-beta production via enhancing the ubiquitination of TRAF3 and TRAF6.SCIENTIFIC REPORTS.
MLA	Chen, Hai-Wei,et al."Ring finger protein 166 potentiates RNA virus-induced interferon-beta production via enhancing the ubiquitination of TRAF3 and TRAF6".SCIENTIFIC REPORTS (2015).