A genetic variation map for chicken with 2.8 million single-nucleotide   polymorphisms

doi:10.1038/nature03156

CORC > 北京大学 > 生命科学学院

	A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms
	Wong, GKS ; Liu, B ; Wang, J ; Zhang, Y ; Yang, X ; Zhang, ZJ ; Meng, QS ; Zhou, J ; Li, DW ; Zhang, JJ ; Ni, PX ; Li, SG ; Ran, LH ; Li, H ; Zhang, JG ; Li, RQ ; Li, ST ; Zheng, HK ; Lin, W ; Li, GY ; Wang, XL ; Zhao, WM ; Li, J ; Ye, C ; Dai, MT ; Ruan, J ; Zhou, Y ; Li, YZ ; He, XM ; Zhang, YZ ; Wang, J ; Huang, XG ; Tong, W ; Chen, J ; Ye, J ; Chen, C ; Wei, N ; Li, GQ ; Dong, L ; Lan, FD ; Sun, YQ ; Zhang, ZP ; Yang, Z ; Yu, YP ; Huang, YQ ; He, DD ; Xi, Y ; Wei, D ; Qi, QH ; Li, WJ ; Shi, JP ; Wang, MH ; Xie, F ; Wang, JJ ; Zhang, XW ; Wang, P ; Zhao, YQ ; Li, N ; Yang, N ; Dong, W ; Hu, SN ; Zeng, CQ ; Zheng, WM ; Hao, BL ; H
刊名	nature
	2004
关键词	QUANTITATIVE TRAIT LOCI BROILER LAYER CROSS GENOME DIVERSITY SEQUENCE MUTATION MARKERS GROWTH SNP
DOI	10.1038/nature03156
英文摘要	We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms ( SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds ( a broiler, a layer and a Chinese silkie) with that of their wild ancestor, red jungle fowl. Subsequent experiments indicate that at least 90% of the variant sites are true SNPs, and at least 70% are common SNPs that segregate in many domestic breeds. Mean nucleotide diversity is about five SNPs per kilobase for almost every possible comparison between red jungle fowl and domestic lines, between two different domestic lines, and within domestic lines - in contrast to the notion that domestic animals are highly inbred relative to their wild ancestors. In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases.; Multidisciplinary Sciences; SCI(E); 0; ARTICLE; 7018; 717-722; 432
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/399790]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wong, GKS,Liu, B,Wang, J,et al. A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms[J]. nature,2004.
APA	Wong, GKS.,Liu, B.,Wang, J.,Zhang, Y.,Yang, X.,...&H.(2004).A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms.nature.
MLA	Wong, GKS,et al."A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms".nature (2004).