Chitin-Induced Dimerization Activates a Plant Immune Receptor

doi:10.1126/science.1218867

CORC > 北京大学 > 生命科学学院

	Chitin-Induced Dimerization Activates a Plant Immune Receptor
	Liu, Tingting ; Liu, Zixu ; Song, Chuanjun ; Hu, Yunfei ; Han, Zhifu ; She, Ji ; Fan, Fangfang ; Wang, Jiawei ; Jin, Changwen ; Chang, Junbiao ; Zhou, Jian-Min ; Chai, Jijie
刊名	science
	2012
关键词	PATTERN-RECOGNITION RECEPTORS ARABIDOPSIS-THALIANA INNATE IMMUNITY KINASE LYSM BINDING DEFENSE PERCEPTION RESISTANCE PROTEINS
DOI	10.1126/science.1218867
英文摘要	Pattern recognition receptors confer plant resistance to pathogen infection by recognizing the conserved pathogen-associated molecular patterns. The cell surface receptor chitin elicitor receptor kinase 1 of Arabidopsis (AtCERK1) directly binds chitin through its lysine motif (LysM)-containing ectodomain (AtCERK1-ECD) to activate immune responses. The crystal structure that we solved of an AtCERK1-ECD complexed with a chitin pentamer reveals that their interaction is primarily mediated by a LysM and three chitin residues. By acting as a bivalent ligand, a chitin octamer induces AtCERK1-ECD dimerization that is inhibited by shorter chitin oligomers. A mutation attenuating chitin-induced AtCERK1-ECD dimerization or formation of nonproductive AtCERK1 dimer by overexpression of AtCERK1-ECD compromises AtCERK1-mediated signaling in plant cells. Together, our data support the notion that chitin-induced AtCERK1 dimerization is critical for its activation.; Multidisciplinary Sciences; SCI(E); 0; ARTICLE; 6085; 1160-1164; 336
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/393466]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Tingting,Liu, Zixu,Song, Chuanjun,et al. Chitin-Induced Dimerization Activates a Plant Immune Receptor[J]. science,2012.
APA	Liu, Tingting.,Liu, Zixu.,Song, Chuanjun.,Hu, Yunfei.,Han, Zhifu.,...&Chai, Jijie.(2012).Chitin-Induced Dimerization Activates a Plant Immune Receptor.science.
MLA	Liu, Tingting,et al."Chitin-Induced Dimerization Activates a Plant Immune Receptor".science (2012).