Fev regulates hematopoietic stem cell development via ERK signaling

doi:10.1182/blood-2012-10-462655

CORC > 北京大学 > 生命科学学院

	Fev regulates hematopoietic stem cell development via ERK signaling
	Wang, Lu ; Liu, Tianhui ; Xu, Linjie ; Gao, Ya ; Wei, Yonglong ; Duan, Caiwen ; Chen, Guo-Qiang ; Lin, Shuo ; Patient, Roger ; Zhang, Bo ; Hong, Dengli ; Liu, Feng
刊名	blood
	2013
关键词	EX-VIVO EXPANSION AORTIC ENDOTHELIUM ZEBRAFISH EMBRYOS SELF-RENEWAL BLOOD DIFFERENTIATION ETS GENE TRANSITION HEDGEHOG
DOI	10.1182/blood-2012-10-462655
英文摘要	Reprogramming of somatic cells to desired cell types holds great promise in regenerative medicine. However, production of transplantable hematopoietic stem cells (HSCs) in vitro by defined factors has not yet been achieved. Therefore, it is critical to fully understand the molecular mechanisms of HSC development in vivo. Here, we show that Fev, an ETS transcription factor, is a pivotal regulator of HSC development in vertebrates. In fev-deficient zebrafish embryos, the first definitive HSC population was compromised and fewer T cells were found in the thymus. Genetic and chemical analyses support a mechanism whereby Fev regulates HSC through direct regulation of ERK signaling. Blastula transplant assay demonstrates that Fev regulation of HSC development is cell autonomous. Experiments performed with purified cord blood show that fev is expressed and functions in primitive HSCs in humans, indicating its conserved role in higher vertebrates. Our data indicate that Fev-ERK signaling is essential for hemogenic endothelium-based HSC development.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000322790500013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Hematology; SCI(E); 15; ARTICLE; 3; 367-375; 122
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/391316]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wang, Lu,Liu, Tianhui,Xu, Linjie,et al. Fev regulates hematopoietic stem cell development via ERK signaling[J]. blood,2013.
APA	Wang, Lu.,Liu, Tianhui.,Xu, Linjie.,Gao, Ya.,Wei, Yonglong.,...&Liu, Feng.(2013).Fev regulates hematopoietic stem cell development via ERK signaling.blood.
MLA	Wang, Lu,et al."Fev regulates hematopoietic stem cell development via ERK signaling".blood (2013).