The tiger genome and comparative analysis with lion and snow leopard   genomes

doi:10.1038/ncomms3433

CORC > 北京大学 > 生命科学学院

	The tiger genome and comparative analysis with lion and snow leopard genomes
	Cho, Yun Sung ; Hu, Li ; Hou, Haolong ; Lee, Hang ; Xu, Jiaohui ; Kwon, Soowhan ; Oh, Sukhun ; Kim, Hak-Min ; Jho, Sungwoong ; Kim, Sangsoo ; Shin, Young-Ah ; Kim, Byung Chul ; Kim, Hyunmin ; Kim, Chang-uk ; Luo, Shu-Jin ; Johnson, Warren E. ; Koepfli, Klaus-Peter ; Schmidt-Kuentzel, Anne ; Turner, Jason A. ; Marker, Laurie ; Harper, Cindy ; Miller, Susan M. ; Jacobs, Wilhelm ; Bertola, Laura D. ; Kim, Tae Hyung ; Lee, Sunghoon ; Zhou, Qian ; Jung, Hyun-Ju ; Xu, Xiao ; Gadhvi, Priyvrat ; Xu, Pengwei ; Xiong, Yingqi ; Luo, Yadan ; Pan, Shengkai ; Gou, Caiyun ; Chu, Xiuhui ; Zhan
刊名	nature communications
	2013
关键词	INITIAL SEQUENCE TASMANIAN DEVIL HIGH-ALTITUDE ALIGNMENT ADAPTATION INSIGHTS DATABASE TOOL CONSERVATION TRANSCRIPTS
DOI	10.1038/ncomms3433
英文摘要	Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39 > Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G > A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000325533700030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); 53; ARTICLE; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/391148]
专题	生命科学学院
推荐引用方式 GB/T 7714	Cho, Yun Sung,Hu, Li,Hou, Haolong,et al. The tiger genome and comparative analysis with lion and snow leopard genomes[J]. nature communications,2013.
APA	Cho, Yun Sung.,Hu, Li.,Hou, Haolong.,Lee, Hang.,Xu, Jiaohui.,...&Zhan.(2013).The tiger genome and comparative analysis with lion and snow leopard genomes.nature communications.
MLA	Cho, Yun Sung,et al."The tiger genome and comparative analysis with lion and snow leopard genomes".nature communications (2013).