Genomic analyses identify distinct patterns of selection in domesticated   pigs and Tibetan wild boars

doi:10.1038/ng.2811

CORC > 北京大学 > 生命科学学院

	Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars
	Li, Mingzhou ; Tian, Shilin ; Jin, Long ; Zhou, Guangyu ; Li, Ying ; Zhang, Yuan ; Wang, Tao ; Yeung, Carol K. L. ; Chen, Lei ; Ma, Jideng ; Zhang, Jinbo ; Jiang, Anan ; Li, Ji ; Zhou, Chaowei ; Zhang, Jie ; Liu, Yingkai ; Sun, Xiaoqing ; Zhao, Hongwei ; Niu, Zexiong ; Lou, Pinger ; Xian, Lingjin ; Shen, Xiaoyong ; Liu, Shaoqing ; Zhang, Shunhua ; Zhang, Mingwang ; Zhu, Li ; Shuai, Surong ; Bai, Lin ; Tang, Guoqing ; Liu, Haifeng ; Jiang, Yanzhi ; Mai, Miaomiao ; Xiao, Jian ; Wang, Xun ; Zhou, Qi ; Wang, Zhiquan ; Stothard, Paul ; Xue, Ming ; Gao, Xiaolian ; Luo, Zonggang ; Gu, Yiren ; Z
刊名	nature genetics
	2013
关键词	HIGH-FIBER DIETS HIGH-ALTITUDE HUMAN-POPULATIONS BEHAVIOR HYPOXIA ADAPTATION EVOLUTION SOWS PHYLOGEOGRAPHY HYPERTENSION
DOI	10.1038/ng.2811
英文摘要	We report the sequencing at 131x coverage, de novo assembly and analyses of the genome of a female Tibetan wild boar. We also resequenced the whole genomes of 30 Tibetan wild boars from six major distributed locations and 18 geographically related pigs in China. We characterized genetic diversity, population structure and patterns of evolution. We searched for genomic regions under selection, which includes genes that are involved in hypoxia, olfaction, energy metabolism and drug response. Comparing the genome of Tibetan wild boar with those of neighboring Chinese domestic pigs further showed the impact of thousands of years of artificial selection and different signatures of selection in wild boar and domestic pig. We also report genetic adaptations in Tibetan wild boar that are associated with high altitudes and characterize the genetic basis of increased salivation in domestic pig.; Genetics & Heredity; SCI(E); 28; ARTICLE; 12; 1431-U180; 45
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/390732]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Mingzhou,Tian, Shilin,Jin, Long,et al. Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars[J]. nature genetics,2013.
APA	Li, Mingzhou.,Tian, Shilin.,Jin, Long.,Zhou, Guangyu.,Li, Ying.,...&Z.(2013).Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars.nature genetics.
MLA	Li, Mingzhou,et al."Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars".nature genetics (2013).