Evolution and variation of the SARS-CoV genome

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	Evolution and variation of the SARS-CoV genome
	Hu Jianfei ; Wang Jing ; Xu Jing ; Li Wei ; Han Yujun ; Li Yan ; Ji Jia ; Ye Jia ; Xu Zhao ; Zhang Zizhang ; Wei Wei ; Li Songgang ; Wang Jun ; Wang Jian ; Yu Jun ; Yang Huanming
刊名	genomics proteomics bioinformatics
	2003
英文摘要	Knowledge of the evolution of pathogens is of great medical and biological significance to the prevention, diagnosis, and therapy of infectious diseases. In order to understand the origin and evolution of the SARS-CoV (severe acute respiratory syndrome-associated coronavirus), we collected complete genome sequences of all viruses available in GenBank, and made comparative analyses with the SARS-CoV. Genomic signature analysis demonstrates that the coronaviruses all take the TGTT as their richest tetranucleotide except the SARS-CoV. A detailed analysis of the forty-two complete SARS-CoV genome sequences revealed the existence of two distinct genotypes, and showed that these isolates could be classified into four groups. Our manual analysis of the BLASTN results demonstrates that the HE (hemagglutinin-esterase) gene exists in the SARS-CoV, and many mutations made it unfamiliar to us.; PubMed; 0; 3; 216-25; 1
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/346458]
专题	生命科学学院
推荐引用方式 GB/T 7714	Hu Jianfei,Wang Jing,Xu Jing,et al. Evolution and variation of the SARS-CoV genome[J]. genomics proteomics bioinformatics,2003.
APA	Hu Jianfei.,Wang Jing.,Xu Jing.,Li Wei.,Han Yujun.,...&Yang Huanming.(2003).Evolution and variation of the SARS-CoV genome.genomics proteomics bioinformatics.
MLA	Hu Jianfei,et al."Evolution and variation of the SARS-CoV genome".genomics proteomics bioinformatics (2003).