The crystal structure of human adenylate kinase 6: An adenylate kinase   localized to the cell nucleus

doi:10.1073/pnas.0407459102

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	The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus
	Ren, H ; Wang, LY ; Bennett, M ; Liang, YH ; Zheng, XF ; Lu, F ; Li, LF ; Nan, J ; Luo, M ; Eriksson, S ; Zhang, CM ; Su, XD
刊名	proceedings of the national academy of sciences of the united states of america
	2005
关键词	x-ray crystallography nuclear localization nucleoticle metabolism phosphotransfer networks NUCLEOSIDE MONOPHOSPHATE KINASES CDNA CLONING PROTEIN EXPRESSION CRYSTALLIZATION PHOSPHOTRANSFER IDENTIFICATION SEQUENCES ALIGNMENT QUALITY
DOI	10.1073/pnas.0407459102
英文摘要	Adenylate kinases (AKs) play important roles in nucleotide metabolism in all organisms and in cellular energetics by means of phosphotransfer networks in eukaryotes. The crystal structure of a human AK named AK6 was determined by in-house sulfur sing le-wavelength anomalous dispersion phasing methods and refined to 2.0-Angstrom resolution with a free R factor of 21.8%. Sequence analyses revealed that human AK6 belongs to a distinct subfamily of AKs present in all eukaryotic organisms sequenced so far. Enzymatic assays show that human AK6 has properties similar with other AKs, particularly with AK5. Fluorescence microscopy showed that human AK6 is localized predominantly to the nucleus of HeLa cells. The identification of a nuclear-localized AK sheds light on nucleotide metabolism in the nucleus and the energetic communication between mitochondria and nucleus by means of phosphotransfer networks.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000226315700010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); PubMed; 61; ARTICLE; 2; 303-308; 102
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/346457]
专题	生命科学学院
推荐引用方式 GB/T 7714	Ren, H,Wang, LY,Bennett, M,et al. The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus[J]. proceedings of the national academy of sciences of the united states of america,2005.
APA	Ren, H.,Wang, LY.,Bennett, M.,Liang, YH.,Zheng, XF.,...&Su, XD.(2005).The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus.proceedings of the national academy of sciences of the united states of america.
MLA	Ren, H,et al."The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus".proceedings of the national academy of sciences of the united states of america (2005).