Targeting of hepatoma cell and suppression of tumor growth by a novel   12mer peptide fused to superantigen TSST-1

doi:10.2119/2006-00011.Jiang

CORC > 北京大学 > 生命科学学院

	Targeting of hepatoma cell and suppression of tumor growth by a novel 12mer peptide fused to superantigen TSST-1
	Jiang, Yong-Qiang ; Wang, Hai-Rong ; Li, Han-Ping ; Hao, Huai-Jie ; Zheng, Yu-Ling ; Gu, Jun
刊名	分子药学
	2006
关键词	HUMAN COLON-CARCINOMA IN-VIVO DRUG-DELIVERY PROTEIN LYMPHOCYTES THERAPY
DOI	10.2119/2006-00011.Jiang
英文摘要	Hepatocellular carcinoma (HCC), one of the most common and malignant tumors worldwide, is unresponsive to any of the available therapies. Using intact HCC cells as therapeutic targets, we isolated a novel peptide, denoted HCC79 (KSLSRHDHIHHH), from a phage display peptide library. HCC79 can bind to hepatoma cell membranes with high affinity and specificity. Remarkably, competitive binding assays demonstrated that HCC79 competed with HAb25, a specific antibody for HCC, in binding to hepatoma cells. The corresponding synthetic peptide did not inhibit tumor proliferation directly, but repressed tumor invasion significantly in a cell migration assay. Moreover, we explored the potential of the selected peptide to deliver a superantigen (SAg) to cancer cells, to attain a significant cell-targeting effect. When the peptide is fused to the TSST-1 SAg, the resulting fusion protein could bind to hepatoma cells with high affinity in vitro and improved the tumor inhibition effect by activating T lymphocyte cells in vitro and in vivo, compared with TSST-1 alone. Taken together, our results indicate that this peptide and its future derivatives may have the potential to be developed into highly specific therapeutic agents against cancer.; Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental; SCI(E); PubMed; 8; ARTICLE; 4-6; 81-87; 12
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/345767]
专题	生命科学学院
推荐引用方式 GB/T 7714	Jiang, Yong-Qiang,Wang, Hai-Rong,Li, Han-Ping,et al. Targeting of hepatoma cell and suppression of tumor growth by a novel 12mer peptide fused to superantigen TSST-1[J]. 分子药学,2006.
APA	Jiang, Yong-Qiang,Wang, Hai-Rong,Li, Han-Ping,Hao, Huai-Jie,Zheng, Yu-Ling,&Gu, Jun.(2006).Targeting of hepatoma cell and suppression of tumor growth by a novel 12mer peptide fused to superantigen TSST-1.分子药学.
MLA	Jiang, Yong-Qiang,et al."Targeting of hepatoma cell and suppression of tumor growth by a novel 12mer peptide fused to superantigen TSST-1".分子药学 (2006).