Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis

CORC > 北京大学 > 生命科学学院

	Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis
	Yao, Yisha ; Yang, Yang ; Zhu, Wei-Guo
刊名	current pharmaceutical design
	2014
关键词	Sirtuin post-translational modification aging metabolism genomic stability apoptosis autophagy PANCREATIC BETA-CELLS FATTY-ACID OXIDATION DNA-DAMAGE RESPONSE SACCHAROMYCES-CEREVISIAE LIFE-SPAN HISTONE H3 SIRT1 DEACETYLASE CALORIE RESTRICTION CAENORHABDITIS-ELEGANS CELLULAR SENESCENCE
英文摘要	Sir2-like proteins, known as sirtuins, have been under a spotlight in the realm of aging because of their positive effect on longevity in Saccharomyces. cerevisiae. Because Sir2 has been identified as a NAD(+)-dependent histone deacetylase, researchers have attributed its lifespan-extending utilities to gene silencing. Similar phenomena are found in multicellular eukaryotes by seemingly different mechanisms. In mammals, seven sirtuin homologs (SIRT1-7) have been identified, with varied cellular locations and molecular functions. Sirtuins target a wide spectrum of molecules for diversified post-translational modifications, thereby exerting multiple physiological benefits. The roles of sirtuins in cancer are still ambiguous, although they have been extensively studied. In this review, we summarize the multiple physiological roles played by sirtuins and their putative mechanisms, especially in cancer.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000334311500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Pharmacology & Pharmacy; SCI(E); PubMed; 6; ARTICLE; zhuweiguo@bjmu.edu.cn; 11; 1614-1624; 20
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342810]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yao, Yisha,Yang, Yang,Zhu, Wei-Guo. Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis[J]. current pharmaceutical design,2014.
APA	Yao, Yisha,Yang, Yang,&Zhu, Wei-Guo.(2014).Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis.current pharmaceutical design.
MLA	Yao, Yisha,et al."Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis".current pharmaceutical design (2014).