Neuronal activity alters BDNF-TrkB signaling kinetics and downstream   functions

doi:10.1242/jcs.139964

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	Neuronal activity alters BDNF-TrkB signaling kinetics and downstream functions
	Guo, Wei ; Ji, Yuanyuan ; Wang, Shudan ; Sun, Yun ; Lu, Bai
刊名	journal of cell science
	2014
关键词	Signal transduction Signaling kinetics Neurotrophin Neuronal activity Neuronal surface receptor DIRECT-CURRENT STIMULATION LONG-TERM-MEMORY HIPPOCAMPAL-NEURONS NEUROTROPHIC FACTOR DENDRITIC GROWTH NEURODEGENERATIVE DISEASES SYNAPTIC PLASTICITY SURFACE EXPRESSION RECEPTOR PROTEIN
DOI	10.1242/jcs.139964
英文摘要	Differential kinetics of the same signaling pathway might elicit different cellular outcomes. Here, we show that high-frequency neuronal activity converts BDNF-induced TrkB (also known as NTRK2) signaling from a transient to a sustained mode. A prior depolarization (15 mM KCl, 1 hour) resulted in a long-lasting (>24 hours) activation of the TrkB receptor and its downstream signaling, which otherwise lasts less than an hour. The long-term potentiation (LTP)-inducing theta-burst stimulation but not the long-term depression (LTD)-inducing low-frequency stimulation also induced sustained activation of TrkB. This sustained signaling facilitated dendritic branching and rescued neuronal apoptosis induced by glutamate. The change in TrkB signaling kinetics is mediated by Ca2+ elevation and CaMKII activation, leading to an increase in TrkB expression on the neuronal surface. Physical exercise also alters the kinetics of TrkB phosphorylation induced by exogenous BDNF. Sustained TrkB signaling might serve as a key mechanism underlying the synergistic effects of neuronal activity and BDNF.; Cell Biology; SCI(E); PubMed; 3; ARTICLE; bai.lu@biomed.tsinghua.edu.cn; 10; 2249-2260; 127
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342330]
专题	生命科学学院
推荐引用方式 GB/T 7714	Guo, Wei,Ji, Yuanyuan,Wang, Shudan,et al. Neuronal activity alters BDNF-TrkB signaling kinetics and downstream functions[J]. journal of cell science,2014.
APA	Guo, Wei,Ji, Yuanyuan,Wang, Shudan,Sun, Yun,&Lu, Bai.(2014).Neuronal activity alters BDNF-TrkB signaling kinetics and downstream functions.journal of cell science.
MLA	Guo, Wei,et al."Neuronal activity alters BDNF-TrkB signaling kinetics and downstream functions".journal of cell science (2014).