A Unified Nomenclature and Amino Acid Numbering for Human PTEN

doi:10.1126/scisignal.2005560

CORC > 北京大学 > 生命科学学院

	A Unified Nomenclature and Amino Acid Numbering for Human PTEN
	Pulido, Rafael ; Baker, Suzanne J. ; Barata, Joao T. ; Carracedo, Arkaitz ; Cid, Victor J. ; Chin-Sang, Ian D. ; Dave, Vrushank ; den Hertog, Jeroen ; Devreotes, Peter ; Eickholt, Britta J. ; Eng, Charis ; Furnari, Frank B. ; Georgescu, Maria-Magdalena ; Gericke, Arne ; Hopkins, Benjamin ; Jiang, Xeujun ; Lee, Seung-Rock ; Loesche, Mathias ; Malaney, Prerna ; Matias-Guiu, Xavier ; Molina, Maria ; Pandolfi, Pier Paolo ; Parsons, Ramon ; Pinton, Paolo ; Rivas, Carmen ; Rocha, Rafael M. ; Rodriguez, Manuel S. ; Ross, Alonzo H. ; Serrano, Manuel ; Stambolic, Vuk ; Stile
刊名	science signaling
	2014
关键词	TUMOR-SUPPRESSOR FUNCTION PHOSPHATASE-ACTIVITY GENE PTEN/MMAC1 MUTATIONS CANCER LOCALIZATION ASSOCIATION GROWTH
DOI	10.1126/scisignal.2005560
英文摘要	The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P-3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338511700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Cell Biology; SCI(E); PubMed; 16; ARTICLE; rpulidomurillo@gmail.com; 332; pe15; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342307]
专题	生命科学学院
推荐引用方式 GB/T 7714	Pulido, Rafael,Baker, Suzanne J.,Barata, Joao T.,et al. A Unified Nomenclature and Amino Acid Numbering for Human PTEN[J]. science signaling,2014.
APA	Pulido, Rafael.,Baker, Suzanne J..,Barata, Joao T..,Carracedo, Arkaitz.,Cid, Victor J..,...&Stile.(2014).A Unified Nomenclature and Amino Acid Numbering for Human PTEN.science signaling.
MLA	Pulido, Rafael,et al."A Unified Nomenclature and Amino Acid Numbering for Human PTEN".science signaling (2014).