Perceptual Learning Improves Adult Amblyopic Vision Through Rule-Based   Cognitive Compensation

doi:10.1167/iovs.13-13739

CORC > 北京大学 > 生命科学学院

	Perceptual Learning Improves Adult Amblyopic Vision Through Rule-Based Cognitive Compensation
	Zhang, Jun-Yun ; Cong, Lin-Juan ; Klein, Stanley A. ; Levi, Dennis M. ; Yu, Cong
刊名	investigative ophthalmology visual science
	2014
关键词	amblyopia perceptual learning orientation PRIMARY VISUAL-CORTEX POSITION DISCRIMINATION CONTRAST SENSITIVITY STRABISMIC AMBLYOPIA RECEPTIVE FIELDS CORTICAL MAPS SPECIFICITY PLASTICITY REORGANIZATION ORIENTATION
DOI	10.1167/iovs.13-13739
英文摘要	PURPOSE. We investigated whether perceptual learning in adults with amblyopia could be enabled to transfer completely to an orthogonal orientation, which would suggest that amblyopic perceptual learning results mainly from high-level cognitive compensation, rather than plasticity in the amblyopic early visual brain. METHODS. Nineteen adults (mean age = 22.5 years) with anisometropic and/or strabismic amblyopia were trained following a training-plus-exposure (TPE) protocol. The amblyopic eyes practiced contrast, orientation, or Vernier discrimination at one orientation for six to eight sessions. Then the amblyopic or nonamblyopic eyes were exposed to an orthogonal orientation via practicing an irrelevant task. Training was first performed at a lower spatial frequency (SF), then at a higher SF near the cutoff frequency of the amblyopic eye. RESULTS. Perceptual learning was initially orientation specific. However, after exposure to the orthogonal orientation, learning transferred to an orthogonal orientation completely. Reversing the exposure and training order failed to produce transfer. Initial lower SF training led to broad improvement of contrast sensitivity, and later higher SF training led to more specific improvement at high SFs. Training improved visual acuity by 1.5 to 1.6 lines (P < 0.001) in the amblyopic eyes with computerized tests and a clinical E acuity chart. It also improved stereoacuity by 53% (P < 0.001). CONCLUSIONS. The complete transfer of learning suggests that perceptual learning in amblyopia may reflect high-level learning of rules for performing a visual discrimination task. These rules are applicable to new orientations to enable learning transfer. Therefore, perceptual learning may improve amblyopic vision mainly through rule-based cognitive compensation.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335913100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Ophthalmology; SCI(E); PubMed; 21; ARTICLE; zhangjunyun@pku.edu.cn; yucong@pku.edu.cn; 4; 2020-2030; 55
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/323369]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Zhang, Jun-Yun,Cong, Lin-Juan,Klein, Stanley A.,et al. Perceptual Learning Improves Adult Amblyopic Vision Through Rule-Based Cognitive Compensation[J]. investigative ophthalmology visual science,2014.
APA	Zhang, Jun-Yun,Cong, Lin-Juan,Klein, Stanley A.,Levi, Dennis M.,&Yu, Cong.(2014).Perceptual Learning Improves Adult Amblyopic Vision Through Rule-Based Cognitive Compensation.investigative ophthalmology visual science.
MLA	Zhang, Jun-Yun,et al."Perceptual Learning Improves Adult Amblyopic Vision Through Rule-Based Cognitive Compensation".investigative ophthalmology visual science (2014).