Viral-Inducible Argonaute18 Confers Broad-Spectrum Virus Resistance in   Rice by Sequestering A Host MicroRNA

doi:10.7554/eLife.05733

CORC > 北京大学 > 生命科学学院

	Viral-Inducible Argonaute18 Confers Broad-Spectrum Virus Resistance in Rice by Sequestering A Host MicroRNA
	Wu, Jianguo ; Yang, Zhirui ; Wang, Yu ; Zheng, Lijia ; Ye, Ruiqiang ; Ji, Yinghua ; Zhao, Shanshan ; Ji, Shaoyi ; Liu, Ruofei ; Xu, Le ; Zheng, Hong ; Zhou, Yijun ; Zhang, Xin ; Cao, Xiaofeng ; Xie, Lianhui ; Wu, Zujian ; Qi, Yijun ; Li, Yi
刊名	elife
	2015
关键词	SMALL RNAS ANTIVIRAL IMMUNITY STRUCTURAL BASIS DICER-LIKE ARABIDOPSIS PLANTS COMPLEXES PROTEINS PATHWAYS SLICER
DOI	10.7554/eLife.05733
英文摘要	Viral pathogens are a major threat to rice production worldwide. Although RNA interference (RNAi) is known to mediate antiviral immunity in plant and animal models, the mechanism of antiviral RNAi in rice and other economically important crops is poorly understood. Here, we report that rice resistance to evolutionarily diverse viruses requires Argonaute18 (AGO18). Genetic studies reveal that the antiviral function of AGO18 depends on its activity to sequester microRNA168 (miR168) to alleviate repression of rice AGO1 essential for antiviral RNAi. Expression of miR168-resistant AGO1a in ago18 background rescues or increases rice antiviral activity. Notably, stable transgenic expression of AGO18 confers broad-spectrum virus resistance in rice. Our findings uncover a novel cooperative antiviral activity of two distinct AGO proteins and suggest a new strategy for the control of viral diseases in rice.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349462700004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biology; SCI(E); PubMed; 7; ARTICLE; wuzujian@126.com; qiyijun@tsinghua.edu.cn; liyi@pku.edu.cn; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/319914]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wu, Jianguo,Yang, Zhirui,Wang, Yu,et al. Viral-Inducible Argonaute18 Confers Broad-Spectrum Virus Resistance in Rice by Sequestering A Host MicroRNA[J]. elife,2015.
APA	Wu, Jianguo.,Yang, Zhirui.,Wang, Yu.,Zheng, Lijia.,Ye, Ruiqiang.,...&Li, Yi.(2015).Viral-Inducible Argonaute18 Confers Broad-Spectrum Virus Resistance in Rice by Sequestering A Host MicroRNA.elife.
MLA	Wu, Jianguo,et al."Viral-Inducible Argonaute18 Confers Broad-Spectrum Virus Resistance in Rice by Sequestering A Host MicroRNA".elife (2015).