Calcium waves initiating from the anomalous subdiffusive calcium sparks

doi:10.1098/rsif.2013.0934

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	Calcium waves initiating from the anomalous subdiffusive calcium sparks
	Chen, Xi ; Guo, Liang ; Kang, Jianhong ; Huo, Yunlong ; Wang, Shiqiang ; Tan, Wenchang
刊名	journal of the royal society interface
	2014
关键词	calcium wave anomalous subdiffusion calcium spark numerical simulation cardiac myocyte ISOLATED CARDIAC MYOCYTES RETICULUM CA2+ RELEASE SARCOPLASMIC-RETICULUM CONFOCAL MICROSCOPY SKELETAL-MUSCLE HEART-MUSCLE MODEL CELLS CHANNEL ACTIVATION
DOI	10.1098/rsif.2013.0934
英文摘要	The objective of the study is to investigate the propagation of Ca2+ waves in full-width cardiac myocytes and carry out sensitivity analysis to study the effects of various physiological parameters on global Ca2+ waves. Based on the anomalous subdiffusion of Ca2+ sparks, a mathematical model was proposed to characterize the Ca2+ waves. The computed results were in agreement with the experimental measurements using confocal microscopy. This model includes variables of current through the Ca2+ release unit (CRU; I-CRU), duration of current flow through CRU (T-open), Ca2+ sensitivity parameter (K), the longitudinal and transverse spatial separation of CRUs (l(x) and l(y), where x denotes longitudinal direction (x-axis) and y denotes transverse direction (y-axis)) and Ca2+ diffusion coefficients (D-x, D-y). The spatio-temporal mechanism of the anomalous Ca2+ sparks led to results that were different from those based on Fick's law. The major findings were reported as: I-CRU affected the dynamic properties of Ca2+ waves more significantly than T-open; the effect of K on the properties of Ca2+ waves was negligible; l(y) affected the amplitude significantly, but l(x) affected the longitudinal velocity significantly; in turn, the limitation and significance of the study are discussed.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000332384600015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); EI; PubMed; 1; ARTICLE; tanwch@mech.pku.edu.cn; 91; 20130934; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/315638]
专题	生命科学学院工学院
推荐引用方式 GB/T 7714	Chen, Xi,Guo, Liang,Kang, Jianhong,et al. Calcium waves initiating from the anomalous subdiffusive calcium sparks[J]. journal of the royal society interface,2014.
APA	Chen, Xi,Guo, Liang,Kang, Jianhong,Huo, Yunlong,Wang, Shiqiang,&Tan, Wenchang.(2014).Calcium waves initiating from the anomalous subdiffusive calcium sparks.journal of the royal society interface.
MLA	Chen, Xi,et al."Calcium waves initiating from the anomalous subdiffusive calcium sparks".journal of the royal society interface (2014).