Genome wide association for substance dependence: convergent results   from epidemiologic and research volunteer samples

doi:10.1186/1471-2350-9-113

CORC > 北京大学 > 生命科学学院

	Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples
	Johnson, Catherine ; Drgon, Tomas ; Liu, Qing-Rong ; Zhang, Ping-Wu ; Walther, Donna ; Li, Chuan-Yun ; Anthony, James C. ; Ding, Yulan ; Eaton, William W. ; Uhl, George R.
刊名	bmc medical genetics
	2008
关键词	FAGERSTROM TOLERANCE QUESTIONNAIRE DIAGNOSTIC-INTERVIEW-SCHEDULE ADDICTION MOLECULAR-GENETICS NICOTINE DEPENDENCE INFORMED CONSENT POLYSUBSTANCE ABUSERS VULNERABILITY LOCI SIZE CALCULATIONS RESPONSE BIAS RISK RATIOS
DOI	10.1186/1471-2350-9-113
英文摘要	Background: Dependences on addictive substances are substantially-heritable complex disorders whose molecular genetic bases have been partially elucidated by studies that have largely focused on research volunteers, including those recruited in Baltimore. Maryland. Subjects recruited from the Baltimore site of the Epidemiological Catchment Area (ECA) study provide a potentially-useful comparison group for possible confounding features that might arise from selecting research volunteer samples of substance dependent and control individuals. We now report novel SNP (single nucleotide polymorphism) genome wide association (GWA) results for vulnerability to substance dependence in ECA participants, who were initially ascertained as members of a probability sample from Baltimore, and compare the results to those from ethnically-matched Baltimore research volunteers. Results: We identify substantial overlap between the home address zip codes reported by members of these two samples. We find overlapping clusters of SNPs whose allele frequencies differ with nominal significance between substance dependent vs control individuals in both samples. These overlapping clusters of nominally-positive SNPs identify 172 genes in ways that are never found by chance in Monte Carlo simulation studies. Comparison with data from human expressed sequence tags suggests that these genes are expressed in brain, especially in hippocampus and amygdala, to extents that are greater than chance. Conclusion: The convergent results from these probability sample and research volunteer sample datasets support prior genome wide association results. They fail to support the idea that large portions of the molecular genetic results for vulnerability to substance dependence derive from factors that are limited to research volunteers.; Genetics & Heredity; SCI(E); 19; ARTICLE; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/247660]
专题	生命科学学院
推荐引用方式 GB/T 7714	Johnson, Catherine,Drgon, Tomas,Liu, Qing-Rong,et al. Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples[J]. bmc medical genetics,2008.
APA	Johnson, Catherine.,Drgon, Tomas.,Liu, Qing-Rong.,Zhang, Ping-Wu.,Walther, Donna.,...&Uhl, George R..(2008).Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples.bmc medical genetics.
MLA	Johnson, Catherine,et al."Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples".bmc medical genetics (2008).