Insights into the evolution of gene organization and multidrug   resistance from Klebsiella pneumoniae plasmid pKF3-140

doi:10.1016/j.gene.2013.01.050

CORC > 北京大学 > 生命科学学院

	Insights into the evolution of gene organization and multidrug resistance from Klebsiella pneumoniae plasmid pKF3-140
	Bai, Jie ; Liu, Qi ; Yang, Yang ; Wang, Junrong ; Yang, Yanmei ; Li, Jinsong ; Li, Peizhen ; Li, Xueying ; Xi, Yali ; Ying, Jun ; Ren, Ping ; Yang, Lei ; Ni, Liyan ; Wu, Jinyu ; Bao, Qiyu ; Zhou, Tieli
刊名	gene
	2013
关键词	Evolution Gene organization Multidrug resistance K. pneumoniae Plasmid pKF3-140 COMPLETE NUCLEOTIDE-SEQUENCE ESCHERICHIA-COLI SULFONAMIDE RESISTANCE DIHYDROPTEROATE SYNTHASE DIHYDROFOLATE-REDUCTASE COMPARATIVE GENOMICS BACTERIA METHYLTRANSFERASES FAMILIES INTEGRON
DOI	10.1016/j.gene.2013.01.050
英文摘要	Plasmid-mediated transfer of drug-resistance genes among various bacterial species is considered one of the most important mechanisms for the spread of multidrug resistance. To gain insights into the evolution of gene organization and antimicrobial resistance in clinical bacterial samples, a complete plasmid genome of Klebsiella pneumoniae pKF3-140 is determined, which has a circular chromosome of 147,416 bp in length. Among the 203 predicted genes, 142 have function assignment and about 50 appear to be involved in plasmid replication, maintenance, conjugative transfer, iron acquisition and transport, and drug resistance. Extensive comparative genomic analyses revealed that pKF3-140 exhibits a rather low sequence similarity and structural conservation with other reported K. pneumoniae plasmids. In contrast, the overall organization of pKF3-140 is highly similar to Escherichia coli plasmids p1ESCUM and pUTI89, which indicates the possibility that K. pneumoniae pKF3-140 may have a potential origin in E. coli. Meanwhile, interestingly, several drug resistant genes show high similarity to the plasmid pU302L in Salmonella enterica serovar Typhimurium U302 strain G8430 and the plasmid pK245 in K. pneumoniae. This mosaic pattern of sequence similarities suggests that pKF3-140 might have arisen from E. coli and acquired the resistance genes from a variety of enteric bacteria and underscores the importance of a further understanding of horizontal gene transfer among enteric bacteria. (c) 2013 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000317374300009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Genetics & Heredity; SCI(E); 4; ARTICLE; 1; 60-66; 519
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/225189]
专题	生命科学学院
推荐引用方式 GB/T 7714	Bai, Jie,Liu, Qi,Yang, Yang,et al. Insights into the evolution of gene organization and multidrug resistance from Klebsiella pneumoniae plasmid pKF3-140[J]. gene,2013.
APA	Bai, Jie.,Liu, Qi.,Yang, Yang.,Wang, Junrong.,Yang, Yanmei.,...&Zhou, Tieli.(2013).Insights into the evolution of gene organization and multidrug resistance from Klebsiella pneumoniae plasmid pKF3-140.gene.
MLA	Bai, Jie,et al."Insights into the evolution of gene organization and multidrug resistance from Klebsiella pneumoniae plasmid pKF3-140".gene (2013).