Involvement of neuropeptide Y and Y1 receptor in antinociception in   nucleus raphe magnus of rats

doi:10.1016/S0167-0115(00)00165-8

CORC > 北京大学 > 生命科学学院

	Involvement of neuropeptide Y and Y1 receptor in antinociception in nucleus raphe magnus of rats
	Zhang, YX ; Lundeberg, T ; Yu, LC
刊名	正规肽
	2000
关键词	nucleus raphe magnus (NRM) neuropeptide Y Y1 receptor naloxone hindpaw withdrawal latency (HWL) antinociceptive effect GENE-RELATED PEPTIDE PERIAQUEDUCTAL GREY SUBSTANCE-P BRAIN NALOXONE SUBTYPES LATENCY
DOI	10.1016/S0167-0115(00)00165-8
英文摘要	The nociceptive response latencies increased significantly after intra-nucleus raphe magnus administration of 0.1 or 0.4 nmol of neuropeptide Y, but not 0.04 nmol, in rats. The neuropeptide Y-induced increases in hindpaw withdrawal latency were reversed by following injection of 0.42 nmol of the Y1 antagonist, NPY(28-36). The results indicate that NPY plays an antinociceptive role in nucleus raphe magnus in rats, which is mediated by the Y1 receptor. Furthermore, the neuropeptide Y-induced increases in hindpaw withdrawal latency were attenuated by following intra-nucleus raphe magnus injection of 6 nmol of the opioid antagonist naloxone, indicating that there is an interaction between NPY and opioids in nucleus raphe magnus. (C) 2000 Elsevier Science B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165368100015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Endocrinology & Metabolism; Physiology; SCI(E); PubMed; 24; ARTICLE; 1-3; 109-113; 95
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200608]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, YX,Lundeberg, T,Yu, LC. Involvement of neuropeptide Y and Y1 receptor in antinociception in nucleus raphe magnus of rats[J]. 正规肽,2000.
APA	Zhang, YX,Lundeberg, T,&Yu, LC.(2000).Involvement of neuropeptide Y and Y1 receptor in antinociception in nucleus raphe magnus of rats.正规肽.
MLA	Zhang, YX,et al."Involvement of neuropeptide Y and Y1 receptor in antinociception in nucleus raphe magnus of rats".正规肽 (2000).