The neural pathway of galanin in the hypothalamic arcuatenucleus of   rats: Activation of beta-endorphinergic neurons projecting to   periaqueductal gray matter

doi:10.1002/jnr.21396

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	The neural pathway of galanin in the hypothalamic arcuatenucleus of rats: Activation of beta-endorphinergic neurons projecting to periaqueductal gray matter
	Sun, Yan-Gang ; Gu, Xing-Long ; Yu, Long-Chuan
刊名	journal of neuroscience research
	2007
关键词	antinociception mu-opioid receptor beta-endorphin midbrain periaqueductal gray matter (PAG) arcuate nucleus SPINAL DORSAL HORN OPIOID RECEPTORS ANTINOCICEPTIVE ROLE PROOPIOMELANOCORTIN NEURONS MORPHINE ANTINOCICEPTION MEDIOBASAL HYPOTHALAMUS INTRATHECAL GALANIN NUCLEUS-ACCUMBENS GREY INJECTION MESSENGER-RNA
DOI	10.1002/jnr.21396
英文摘要	We have previously shown that microinjection of galanin into the arcuate nucleus of hypothalamus (ARC) produced antinociceptive effects in rats (Sun et al., 2003a). In this study, the neural pathway of galanin from ARC to midbrain periaqueductal gray (PAG) in nociceptive modulation was investigated. The hindpaw withdrawal latencies (HWLs) with noxious thermal and mechanical stimulation were assessed by the hotplate and the Randall Selitto tests. Intra-ARC administration of 0.1, 0.5, or 1 nmol of galanin induced significant increases in HWLs of rats. The galanin-induced increases in HWLs were inhibited by injection of 10 mu g of the opioid receptor antagonist naloxone or 1 nmol of the mu-opioid receptor antagonist beta-funaltrexamine (beta-FNA) into PAG, suggesting that the antinociceptive effects induced by intra-ARC injection of galanin occur via the neural pathway from ARC to PAG. Furthermore, our results demonstrate that the galaninergic fibers directly innervated the beta-endorphinergic neurons in ARC by immunofluorescent methods. Taken together, our results suggest that galanin produces antinociceptive effects in the ARC of rats by activating the beta-endorphinergic pathway from ARC to PAG. (C) 2007 Wiley-Liss, Inc.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000248971500011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 11; ARTICLE; 11; 2400-2406; 85
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/198277]
专题	生命科学学院
推荐引用方式 GB/T 7714	Sun, Yan-Gang,Gu, Xing-Long,Yu, Long-Chuan. The neural pathway of galanin in the hypothalamic arcuatenucleus of rats: Activation of beta-endorphinergic neurons projecting to periaqueductal gray matter[J]. journal of neuroscience research,2007.
APA	Sun, Yan-Gang,Gu, Xing-Long,&Yu, Long-Chuan.(2007).The neural pathway of galanin in the hypothalamic arcuatenucleus of rats: Activation of beta-endorphinergic neurons projecting to periaqueductal gray matter.journal of neuroscience research.
MLA	Sun, Yan-Gang,et al."The neural pathway of galanin in the hypothalamic arcuatenucleus of rats: Activation of beta-endorphinergic neurons projecting to periaqueductal gray matter".journal of neuroscience research (2007).