Mouse ZAR1-Like (XM_359149) Colocalizes With mRNA Processing Components   and Its Dominant-Negative Mutant Caused Two-Cell-Stage Embryonic Arrest

doi:10.1002/dvdy.22170

CORC > 北京大学 > 生命科学学院

	Mouse ZAR1-Like (XM_359149) Colocalizes With mRNA Processing Components and Its Dominant-Negative Mutant Caused Two-Cell-Stage Embryonic Arrest
	Hu, Jianjun ; Wan, Fengchao ; Zhu, Xiaoquan ; Yuan, Ye ; Ding, Mingxiao ; Ga, Shaorong
刊名	发育动力学
	2010
关键词	mRNA processing body two-cell block Zar1l Zar1 zygotic genome activation ZYGOTIC GENE ACTIVATION GENOME ACTIVATION EARLY EMBRYOGENESIS CHROMATOID BODY GERM-LINE P-BODIES EXPRESSION PIWI PIRNAS CELLS
DOI	10.1002/dvdy.22170
英文摘要	Maternal effect genes and encoding proteins are necessary for nuclear reprogramming and zygotic genome activation. However, the mechanisms that mediate these functions are largely unknown. Here we identified XM_359149, a Zar1-like gene that is predominantly expressed in oocytes and zygotes, which we designated Zar1-like (Zar1l). ZAR1L-EGFP formed multiple cytoplasmic foci in late two-cell-stage embryos. Expression of the ZAR1L C-terminus induced two-cell-stage embryonic arrest, accompanied with abnormal methylation of histone H3K4me2/3 and H3K9me2/3, and marked down-regulation of a group of chromatin modification factors including Dppa2, Dppa4, and Piwil2. When ectopically expressed in somatic cells, ZARIL colocalized with P-body components including ETF2C1(AGO1), EIF2C2(AGO2), DDX6 and LSM14A, and germline-specific chromatoid body components including PIWIL1, PIWIFL2, and LIN28. ZAR1L colocalized with ZAR1 and interacted with human LIN28. Our data suggest that ZAR1L and ZAR1 may comprise a novel family of processing-body/chromatoid-body components that potentially function as RNA regulators in early embryos. Developmental Dynamics 239.407-424, 2010. (C) 2009 Wiley-Liss, Inc.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000274819300004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Anatomy & Morphology; Developmental Biology; SCI(E); PubMed; 16; ARTICLE; 2; 407-424; 239
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162589]
专题	生命科学学院
推荐引用方式 GB/T 7714	Hu, Jianjun,Wan, Fengchao,Zhu, Xiaoquan,et al. Mouse ZAR1-Like (XM_359149) Colocalizes With mRNA Processing Components and Its Dominant-Negative Mutant Caused Two-Cell-Stage Embryonic Arrest[J]. 发育动力学,2010.
APA	Hu, Jianjun,Wan, Fengchao,Zhu, Xiaoquan,Yuan, Ye,Ding, Mingxiao,&Ga, Shaorong.(2010).Mouse ZAR1-Like (XM_359149) Colocalizes With mRNA Processing Components and Its Dominant-Negative Mutant Caused Two-Cell-Stage Embryonic Arrest.发育动力学.
MLA	Hu, Jianjun,et al."Mouse ZAR1-Like (XM_359149) Colocalizes With mRNA Processing Components and Its Dominant-Negative Mutant Caused Two-Cell-Stage Embryonic Arrest".发育动力学 (2010).