Antinociceptive effects induced by injection of the galanin receptor 1   agonist M617 into central nucleus of amygdala in rats

doi:10.1016/j.neulet.2012.07.041

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	Antinociceptive effects induced by injection of the galanin receptor 1 agonist M617 into central nucleus of amygdala in rats
	Li, Jun ; Zhang, Jian Jun ; Xu, Shi-Lian ; Yu, Long-Chuan
刊名	神经科学快报
	2012
关键词	Antinociceptive effect The central nucleus of amygdala Galanin Galanin receptor 1 Hindpaw withdrawal latency M617 CENTRAL-NERVOUS-SYSTEM ARCUATE NUCLEUS SPINAL ANTINOCICEPTION PERIAQUEDUCTAL GREY OPIOID RECEPTORS PAIN MONONEUROPATHY HYPOTHALAMUS INVOLVEMENT INFLAMMATION
DOI	10.1016/j.neulet.2012.07.041
英文摘要	The present study was performed to explore the antinociceptive effects of M617, a selective galanin receptor 1 agonist, in the central nucleus of amygdala (CeA) of rats. Intra-CeA injection of 0.1 nmol, 0.5 nmol and 1 nmol of M617 induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, rats received intra-CeA administration of M617 and galanin. The HWL to noxious thermal and mechanical stimulations increased markedly, and there were no significant differences in HWLs of rats received intra-CeA administration of M617 and galanin. The results demonstrated that intra-CeA injection of M617 induced significant antinociceptive effects in CeA of rats, indicating that galanin receptor 1 may be involved in M617-induced antinociception in the CeA of rats. (C) 2012 Elsevier Ireland Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309319500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 3; ARTICLE; 1; 45-48; 526
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162502]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Jun,Zhang, Jian Jun,Xu, Shi-Lian,et al. Antinociceptive effects induced by injection of the galanin receptor 1 agonist M617 into central nucleus of amygdala in rats[J]. 神经科学快报,2012.
APA	Li, Jun,Zhang, Jian Jun,Xu, Shi-Lian,&Yu, Long-Chuan.(2012).Antinociceptive effects induced by injection of the galanin receptor 1 agonist M617 into central nucleus of amygdala in rats.神经科学快报.
MLA	Li, Jun,et al."Antinociceptive effects induced by injection of the galanin receptor 1 agonist M617 into central nucleus of amygdala in rats".神经科学快报 (2012).