A long-term demasculinization of X-linked intergenic noncoding RNAs in   Drosophila melanogaster

doi:10.1101/gr.165837.113

CORC > 北京大学 > 生命科学学院

	A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster
	Gao, Ge ; Vibranovski, Maria D. ; Zhang, Li ; Li, Zheng ; Liu, Ming ; Zhang, Yong E. ; Li, Xinmin ; Zhang, Wenxia ; Fan, Qichang ; VanKuren, Nicholas W. ; Long, Manyuan ; Wei, Liping
刊名	genome research
	2014
关键词	SEX-CHROMOSOME INACTIVATION BIASED GENE-EXPRESSION CAENORHABDITIS-ELEGANS REGULATORY RNAS EVOLUTION GENOME SPERMATOGENESIS TRANSCRIPTION DIMORPHISM GERMLINE
DOI	10.1101/gr.165837.113
英文摘要	Recent studies have revealed key roles of noncoding RNAs in sex-related pathways, but little is known about the evolutionary forces acting on these noncoding RNAs. Profiling the transcriptome of Drosophila melanogaster with whole-genome tiling arrays found that 15% of male-biased transcribed fragments are intergenic noncoding RNAs (incRNAs), suggesting a potentially important role for incRNAs in sex-related biological processes. Statistical analysis revealed a paucity of male-biased incRNAs and coding genes on the X chromosome, suggesting that similar evolutionary forces could be affecting the genomic organization of both coding and noncoding genes. Expression profiling across germline and somatic tissues further suggested that both male meiotic sex chromosome inactivation (MSCI) and sexual antagonism could contribute to the chromosomal distribution of male-biased incRNAs. Comparative sequence analysis showed that the evolutionary age of male-biased incRNAs is a significant predictor of their chromosomal locations. In addition to identifying abundant sex-biased incRNAs in the fly genome, our work unveils a global picture of the complex interplay between noncoding RNAs and sexual chromosome evolution.; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; SCI(E); PubMed; 8; ARTICLE; mlong@uchicago.edu; weilp@mail.cbi.pku.edu.cn; 4; 629-638; 24
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162452]
专题	生命科学学院
推荐引用方式 GB/T 7714	Gao, Ge,Vibranovski, Maria D.,Zhang, Li,et al. A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster[J]. genome research,2014.
APA	Gao, Ge.,Vibranovski, Maria D..,Zhang, Li.,Li, Zheng.,Liu, Ming.,...&Wei, Liping.(2014).A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster.genome research.
MLA	Gao, Ge,et al."A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster".genome research (2014).