Genomic distribution and possible functions of DNA hydroxymethylation in   the brain

doi:10.1016/j.ygeno.2014.08.020

CORC > 北京大学 > 生命科学学院

	Genomic distribution and possible functions of DNA hydroxymethylation in the brain
	Wen, Lu ; Tang, Fuchou
刊名	genomics
	2014
关键词	5-Hydroxymethylcytosine TET DNA methylation Active DNA demethylation Brain MeCP2 EMBRYONIC STEM-CELLS MEMORY FORMATION NEUROLOGICAL DISEASE BASE-RESOLUTION BINDING DOMAIN WIDE ANALYSIS TET PROTEINS GENE BODIES ADULT BRAIN 5-HYDROXYMETHYLCYTOSINE
DOI	10.1016/j.ygeno.2014.08.020
英文摘要	DNA methylation (5-methylcytosine, 5mC) is involved in many cellular processes and emerges as an important epigenetic player in brain development and memory formation. The recent discovery that 5mC can be oxidized to 5-hydroxymethylcytosine (5hmC) by TET (Ten-Eleven-Translocation) proteins provides novel insights into the dynamic character of 5mC in the brain. The content of 5hmC is remarkably high in the brain, adding further complexity. In this review, we discuss how recent advances have improved our understanding of the possible biological roles of 5hmC and TET proteins in the brain. These advances attribute to various approaches, including the genome-wide approach to map 5hmC in different genomic contexts, the gene knockout/knockdown approach to elucidate the functions of TET proteins and 5hmC, and the biochemical approach to uncover potential 5hmC readers. (C) 2014 Elsevier Inc. All rights reserved.; Biotechnology & Applied Microbiology; Genetics & Heredity; SCI(E); PubMed; 3; REVIEW; wenlu.wl@gmail.com; 5; 341-346; 104
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162441]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wen, Lu,Tang, Fuchou. Genomic distribution and possible functions of DNA hydroxymethylation in the brain[J]. genomics,2014.
APA	Wen, Lu,&Tang, Fuchou.(2014).Genomic distribution and possible functions of DNA hydroxymethylation in the brain.genomics.
MLA	Wen, Lu,et al."Genomic distribution and possible functions of DNA hydroxymethylation in the brain".genomics (2014).