An Enzyme-Responsive Nanogel Carrier Based on PAMAM Dendrimers for Drug   Delivery

doi:10.1021/acsami.6b05567

CORC > 北京大学 > 化学与分子工程学院

	An Enzyme-Responsive Nanogel Carrier Based on PAMAM Dendrimers for Drug Delivery
	Wang, Yao ; Luo, Yiyang ; Zhao, Qiang ; Wang, Zhijian ; Xu, Zejun ; Jia, Xinru
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016
关键词	PAMAM dendrimer enzyme nanogel cross-link drug delivery CROSS-LINKED MICELLES CONTROLLED-RELEASE BIOMEDICAL APPLICATIONS HYDROGEL PARTICLES TRIGGERED RELEASE POLYMER NANOGELS PROTEIN-DELIVERY PERIODATE ANIONS NANOPARTICLES BRAIN
DOI	10.1021/acsami.6b05567
英文摘要	G4 PAMAM dendrimer molecules were modified via covalently conjugating RGDC, RAADyC, and PEG chains on the periphery (Mac-1), by which a nanogel drug carrier with enzyme-sensitivity (NG-1) was constructed through an oxidation reaction by using NaIO4 to initiate the chemical cross-link of the functional groups on the periphery of dendrimers. Mac-1 and NG-1 both had a spherelike shape with a relatively uniform size of 20 nm for Mac-1 and SO nm for NG-1 as evidenced by TEM, SEM, and DLS measurements. NG-1 showed much higher drug loading capacity as compared with that of Mac-1 although the cavities in the dendritic structure were used to encapsulate drug molecules as reported in many literatures. In addition, the size of NG-1 with embedded doxorubicin hydrochloride (DOX) decreased significantly to 15 nm in the presence of elastase, which indicated the decomposition of the nanogel triggered by enzyme, leading to drug release in a sustained manner in vitro. The NG-1 carrier was noncytotoxic and biocompatible, and it achieved the same cytotoxicity as free DOX when the drug molecules were loaded inside. From confocal images, the penetrative process of DOX from nanogel could be clearly observed in 8 h. Such a dendrimer-based nanogel may be a potential nanocarrier for drug delivery in cancer therapy.; National Natural Science Foundation of China [21274004]; SCI(E); EI; PubMed; ARTICLE; xijia@pku.edu.cn; 31; 19900-19907; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/491613]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wang, Yao,Luo, Yiyang,Zhao, Qiang,et al. An Enzyme-Responsive Nanogel Carrier Based on PAMAM Dendrimers for Drug Delivery[J]. ACS APPLIED MATERIALS & INTERFACES,2016.
APA	Wang, Yao,Luo, Yiyang,Zhao, Qiang,Wang, Zhijian,Xu, Zejun,&Jia, Xinru.(2016).An Enzyme-Responsive Nanogel Carrier Based on PAMAM Dendrimers for Drug Delivery.ACS APPLIED MATERIALS & INTERFACES.
MLA	Wang, Yao,et al."An Enzyme-Responsive Nanogel Carrier Based on PAMAM Dendrimers for Drug Delivery".ACS APPLIED MATERIALS & INTERFACES (2016).