Giant molecules: where chemistry, physics, and bio-science meet

doi:10.1007/s11426-016-0436-x

CORC > 北京大学 > 化学与分子工程学院

	Giant molecules: where chemistry, physics, and bio-science meet
	Yin, Guang-Zhong ; Zhang, Wen-Bin ; Cheng, Stephen Z. D.
刊名	SCIENCE CHINA-CHEMISTRY
	2017
关键词	giant molecules molecular nanoparticles protein protein engineering domains NONCANONICAL AMINO-ACIDS DOUBLE-CABLE STRUCTURE POLYMER SOLAR-CELLS SHAPE AMPHIPHILES CRYSTAL-STRUCTURE JANUS PARTICLES CLICK APPROACH FRANK-KASPER MACROMOLECULAR SCIENCE DIRECTED EVOLUTION
DOI	10.1007/s11426-016-0436-x
英文摘要	This feature article focuses on the recent development of giant molecules, which has emerged at the interface among chemistry, physics, and bio-science. Their molecular designs are inspired by natural polymers like proteins and are modularly constructed from molecular nanoparticle building blocks via sequential "click" chemistry. Most important molecular parameters such as topology, composition, and molecular weight can be precisely controlled. Their hierarchical assembly reveals many features reminiscent of both small molecules and proteins yet unusual for conventional synthetic polymers. These features are summarized and compared along with synthetic polymers and proteins. Specifically, examples are given in each category of giant molecules to illustrate the characteristics of their hierarchical assembly across different length, time and energy scales. The idea of "artificial domain" is presented in analogy to the structural domains in proteins. By doing so, we aim to develop a rational and modular approach toward functional materials. The factors that dominate the materials functions are discussed with respect to the precision and dynamics of the assembly. The complexity of structure-function relationship is acknowledged, which suggests that there is still a long way to go toward the convergence of synthetic polymers and biopolymers.; National Natural Science Foundation of China [21674003, 21474003, 91427304]; National High Technology Research and Development Program of China [2015AA020941]; National Science Foundation of US [DMR-0906898, DMR-1409972]; SCI(E); ARTICLE; 3; 338-352; 60
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/474935]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yin, Guang-Zhong,Zhang, Wen-Bin,Cheng, Stephen Z. D.. Giant molecules: where chemistry, physics, and bio-science meet[J]. SCIENCE CHINA-CHEMISTRY,2017.
APA	Yin, Guang-Zhong,Zhang, Wen-Bin,&Cheng, Stephen Z. D..(2017).Giant molecules: where chemistry, physics, and bio-science meet.SCIENCE CHINA-CHEMISTRY.
MLA	Yin, Guang-Zhong,et al."Giant molecules: where chemistry, physics, and bio-science meet".SCIENCE CHINA-CHEMISTRY (2017).