Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for   red light-induced drug release

doi:10.1088/1361-6528/aa5e74

CORC > 北京大学 > 化学与分子工程学院

	Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for red light-induced drug release
	Chai, Shiqiang ; Guo, Yu ; Zhang, Zhenyu ; Chai, Zhen ; Ma, Yurong ; Qi, Limin
刊名	NANOTECHNOLOGY
	2017
关键词	mesoporous silica nanoparticles photodynamic therapy drug delivery cyclodextrin UP-CONVERSION NANOPARTICLES PHOTODYNAMIC THERAPY UPCONVERTING NANOPARTICLES LANTHANIDE NANOPARTICLES CANCER-CELLS DELIVERY NANOCARRIERS DESIGN NANOCONTAINERS THERANOSTICS
DOI	10.1088/1361-6528/aa5e74
英文摘要	Long wavelength light-responsive drug delivery systems based on mesoporous silica nanoparticles (MSNs) have attracted much attention in the last few years. In this paper, a red light (660 nm)-responsive drug delivery system based on low-cost cyclodextrin (CD)-gated MSNs containing a photodynamic therapy (PDT) photosensitizer (Chlorin e6, Ce6) was developed for the first time. The drug release experiment in water demonstrated that with the irradiation of red light, Ce6 can be excited to generate singlet oxygen, which can further cleave the singlet oxygen sensitive linker to trigger the departure of CD and the release of cargo. Further in vitro release experiments confirmed that cargo can be released from MSNs with the irradiation of red light and spread into the entire cell. The relative low power density (0.5Wcm(-2)) of excitation light together with the short irradiation time (one-three min) result in a low light dose (30-90 J cm(-2)) for the drug delivery, contributing to their potential clinical applications.; National Natural Science Foundation of China [21622301, 21473004]; SCI(E); ARTICLE; 14; 28
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/474623]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Chai, Shiqiang,Guo, Yu,Zhang, Zhenyu,et al. Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for red light-induced drug release[J]. NANOTECHNOLOGY,2017.
APA	Chai, Shiqiang,Guo, Yu,Zhang, Zhenyu,Chai, Zhen,Ma, Yurong,&Qi, Limin.(2017).Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for red light-induced drug release.NANOTECHNOLOGY.
MLA	Chai, Shiqiang,et al."Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for red light-induced drug release".NANOTECHNOLOGY (2017).