Mechanistic Study of SmI2-Mediated Reformatsky Reaction for Macrolactam   Formation Using a Cyclopropyl Group as a Probe

doi:10.1002/ijch.201600104

CORC > 北京大学 > 化学与分子工程学院

	Mechanistic Study of SmI2-Mediated Reformatsky Reaction for Macrolactam Formation Using a Cyclopropyl Group as a Probe
	Yang, Shouliang ; Xi, Yumeng ; Chen, Jiahua ; Yang, Zhen
刊名	ISRAEL JOURNAL OF CHEMISTRY
	2017
关键词	bromine carbon macrolactam formation mechanistic study SmI2-mediated Reformatsky reaction ORGANIC-SYNTHESIS TETRAPETALONE-A STREPTOMYCES SP SAMARIUM(II) IODIDE NATURAL-PRODUCTS DRUG DISCOVERY RING HYDROXYLATION LANTHANIDES REDUCTION
DOI	10.1002/ijch.201600104
英文摘要	A mechanistic study using a cyclopropylmethyl radical clock as a probe to investigate the formation of a macrolactam ring via an SmI2-mediated intramolecular Reformatsky reaction is experimentally explored. The results of our study indicate that the key Sm-III-enolate intermediate is formed by cleavage of a C-Br bond in an anion-mediated -elimination, and then eventually undergoes an intramolecular aldol condensation to form the macrolactam ring.; National Science Foundation of China [21372016, 21572009, 21402002]; Guang-dong Natural Science Foundation [2014A030312004, 2016A030306011]; NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]; SCI(E); ARTICLE; 3-4,SI; 331-334; 57
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/474269]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Yang, Shouliang,Xi, Yumeng,Chen, Jiahua,et al. Mechanistic Study of SmI2-Mediated Reformatsky Reaction for Macrolactam Formation Using a Cyclopropyl Group as a Probe[J]. ISRAEL JOURNAL OF CHEMISTRY,2017.
APA	Yang, Shouliang,Xi, Yumeng,Chen, Jiahua,&Yang, Zhen.(2017).Mechanistic Study of SmI2-Mediated Reformatsky Reaction for Macrolactam Formation Using a Cyclopropyl Group as a Probe.ISRAEL JOURNAL OF CHEMISTRY.
MLA	Yang, Shouliang,et al."Mechanistic Study of SmI2-Mediated Reformatsky Reaction for Macrolactam Formation Using a Cyclopropyl Group as a Probe".ISRAEL JOURNAL OF CHEMISTRY (2017).