Cu(I)-Catalyzed Three-Component Coupling of Trifluoromethyl Ketone   N-Tosylhydrazones, Alkynes and Azides: Synthesis of Difluoromethylene   Substituted 1,2,3-Triazoles

doi:10.1002/cjoc.201600888

CORC > 北京大学 > 化学与分子工程学院

	Cu(I)-Catalyzed Three-Component Coupling of Trifluoromethyl Ketone N-Tosylhydrazones, Alkynes and Azides: Synthesis of Difluoromethylene Substituted 1,2,3-Triazoles
	Zhang, Zhikun ; Zhou, Qi ; Yu, Weizhi ; Li, Tianjiao ; Zhang, Yan ; Wang, Jianbo
刊名	CHINESE JOURNAL OF CHEMISTRY
	2017
关键词	Cu(I)-catalysis metal carbene migratory insertion beta-fluoride elimination triazole COPPER-CATALYZED CYCLOADDITION CARBENE MIGRATORY INSERTION 1,4,5-TRISUBSTITUTED 1,2,3-TRIAZOLES REGIOSELECTIVE SYNTHESIS TERMINAL ALKYNES DIAZO-COMPOUNDS ORGANIC AZIDES METAL CARBENE BOND FLUORINE
DOI	10.1002/cjoc.201600888
英文摘要	A CuI-catalyzed three-component coupling of trifluoromethyl ketone N-tosylhydrazones, alkynes and azides has been developed. The reactionrepresents a straightforward method to access difluoromethylene substituted 1,2,3-triazoles. Mechanistically, it has been proposed that the reaction follows a pathway involving the formation of Cu(I)triazolide intermediate, Cu(I) carbene formation, migratory insertion, and -fluoride elimination. Thetransformation is featured by mild conditions, wide substrate scope and high efficiency.; National Basic Research Program of China (973 Program) [2015CB856600]; NSFC [21472004, 21332002]; SCI(E); ARTICLE; 4; 387-391; 35
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/474228]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Zhikun,Zhou, Qi,Yu, Weizhi,et al. Cu(I)-Catalyzed Three-Component Coupling of Trifluoromethyl Ketone N-Tosylhydrazones, Alkynes and Azides: Synthesis of Difluoromethylene Substituted 1,2,3-Triazoles[J]. CHINESE JOURNAL OF CHEMISTRY,2017.
APA	Zhang, Zhikun,Zhou, Qi,Yu, Weizhi,Li, Tianjiao,Zhang, Yan,&Wang, Jianbo.(2017).Cu(I)-Catalyzed Three-Component Coupling of Trifluoromethyl Ketone N-Tosylhydrazones, Alkynes and Azides: Synthesis of Difluoromethylene Substituted 1,2,3-Triazoles.CHINESE JOURNAL OF CHEMISTRY.
MLA	Zhang, Zhikun,et al."Cu(I)-Catalyzed Three-Component Coupling of Trifluoromethyl Ketone N-Tosylhydrazones, Alkynes and Azides: Synthesis of Difluoromethylene Substituted 1,2,3-Triazoles".CHINESE JOURNAL OF CHEMISTRY (2017).