The susceptible HLA class II alleles and their presenting epitope(s) in   Goodpasture&apos;s disease

doi:10.1111/imm.12736

CORC > 北京大学 > 化学与分子工程学院

	The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease
	Xie, Li-jun ; Cui, Zhao ; Chen, Fang-jin ; Pei, Zhi-yong ; Hu, Shui-Yi ; Gu, Qiu-hua ; Jia, Xiao-yu ; Zhu, Li ; Zhou, Xu-jie ; Zhang, Hong ; Liao, Yun-hua ; Lai, Lu-hua ; Hudson, Billy G. ; Zhao, Ming-hui
刊名	IMMUNOLOGY
	2017
关键词	anti- glomerular basement membrane disease epitope Goodpasture&apos HLA MHC PEPTIDE BINDING GBM DISEASE T-CELLS AUTOANTIGEN COMPLEX GLOMERULONEPHRITIS AUTOANTIBODIES AUTOIMMUNITY ASSOCIATION ANTIBODIES s disease
DOI	10.1111/imm.12736
英文摘要	Goodpasture's disease is closely associated with HLA, particularly DRB11501. Other susceptible or protective HLA alleles are not clearly elucidated. The presentation models of epitopes by susceptible HLA alleles are also unclear. We genotyped 140 Chinese patients and 599 controls for four-digit HLA II genes, and extracted the encoding sequences from the IMGT/HLA database. T-cell epitopes of 3(IV)NC1 were predicted and the structures of DR molecule-peptideT-cell receptor were constructed. We confirmed DRB11501 (OR = 46, P = 57 x 10(-28)) to be a risk allele for Goodpasture's disease. Arginine at position 13 (ARG13) (OR = 40, P = 10 x 10(-17)) and proline at position 11 (PRO11) (OR = 40, P = 20 x 10(-17)) on DR1, encoded by DRB11501, were associated with disease susceptibility. (134-148) (HGWISLWKGFSFIMF) was predicted as a T-cell epitope presented by DRB11501. Isoleucine(137), tryptophan(140), glycine(142), phenylalanine(143) and phenylalanine(145), were presented in peptide-binding pockets 1, 4, 6, 7 and 9 of DR2b, respectively. ARG13 in pocket 4 interacts with tryptophan(140) and forms a hydrogen bond. In conclusion, we propose a mechanism for DRB1*1501 susceptibility for Goodpasture's disease through encoding ARG13 and PRO11 on MHC-DR1 chain and presenting T-cell epitope, (134-148), with five critical residues.; Natural Science Foundation of China [81621092, 81622009, 81330020, 81370801, 81400703]; SCI(E); ARTICLE; 4; 395-404; 151
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/471908]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Xie, Li-jun,Cui, Zhao,Chen, Fang-jin,et al. The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease[J]. IMMUNOLOGY,2017.
APA	Xie, Li-jun.,Cui, Zhao.,Chen, Fang-jin.,Pei, Zhi-yong.,Hu, Shui-Yi.,...&Zhao, Ming-hui.(2017).The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease.IMMUNOLOGY.
MLA	Xie, Li-jun,et al."The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease".IMMUNOLOGY (2017).