UV-triggered thiol-disulfide exchange reaction towards tailored   biodegradable hydrogels

doi:10.1039/c5py01925g

CORC > 北京大学 > 化学与分子工程学院

	UV-triggered thiol-disulfide exchange reaction towards tailored biodegradable hydrogels
	Wang, Linlin ; Li, Lei ; Wang, Xing ; Huang, Da ; Yang, Fei ; Shen, Hong ; Li, Zichen ; Wu, Decheng
刊名	POLYMER CHEMISTRY
	2016
关键词	HIGH MECHANICAL STRENGTH PHOTO-CLICK CHEMISTRY DRUG-RELEASE BIOMEDICAL APPLICATIONS COMPOSITE HYDROGELS HYBRID HYDROGELS CELL-CULTURE SCAFFOLDS POLYMERS NANOPARTICLES
DOI	10.1039/c5py01925g
英文摘要	We report a method of utilizing a UV-triggered thiol-disulfide exchange reaction for constructing biodegradable hydrogels with tailored properties from a water-soluble comb-like polymer of P(EMA-SS-PEG), a polyethylene glycol grafted poly(ethyl methacrylate) derivative with the disulfide linkage as the grafting point. This photochemical method provides precise spatiotemporal control over the structures and properties of disulfide-crosslinked hydrogels. By varying the irradiation time, we facilely adjust the cross-linking degree of hydrogels, thereby regulating their morphology, mechanical properties, hydrophilic properties, and swelling ratio. The photochemical method can easily fabricate macro-micro-customized patterned hydrogels, indicating its precise spatial control on the photochemical gelation process. In addition, the tailor-made biodegradable hydrogels can achieve tunable absorption and release behaviors of RB dyes, proving their potential application in controlled drug delivery.; MOST [2014CB932200, 2014BAI11B04]; Young Thousand Talents Program; NSFC [21504096, 21174147, 21474115]; SCI(E); ARTICLE; dcwu@iccas.ac.cn; 7; 1429-1438; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/438953]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wang, Linlin,Li, Lei,Wang, Xing,et al. UV-triggered thiol-disulfide exchange reaction towards tailored biodegradable hydrogels[J]. POLYMER CHEMISTRY,2016.
APA	Wang, Linlin.,Li, Lei.,Wang, Xing.,Huang, Da.,Yang, Fei.,...&Wu, Decheng.(2016).UV-triggered thiol-disulfide exchange reaction towards tailored biodegradable hydrogels.POLYMER CHEMISTRY.
MLA	Wang, Linlin,et al."UV-triggered thiol-disulfide exchange reaction towards tailored biodegradable hydrogels".POLYMER CHEMISTRY (2016).