In-vivo fluorescence imaging of adenosine 5 &apos;-triphosphate

doi:10.1016/j.trac.2016.03.020

CORC > 北京大学 > 化学与分子工程学院

	In-vivo fluorescence imaging of adenosine 5 '-triphosphate
	Dong, Jiantong ; Zhao, Meiping
刊名	TRAC-TRENDS IN ANALYTICAL CHEMISTRY
	2016
关键词	Adenosine-5 &apos Aptamers Biosensors Fluorescence indicators Genetically encoded fluorescent reporters Imaging in vivo Intracellular detection Nanomaterials Organic fluorescent probes Subcellular RESONANCE ENERGY-TRANSFER LIVING CELLS GRAPHENE OXIDE ATP CONCENTRATION REAL-TIME FREE ADP NUCLEOSIDE POLYPHOSPHATES MAMMALIAN-CELLS DRUG-DELIVERY APTAMER -triphosphate
DOI	10.1016/j.trac.2016.03.020
英文摘要	As a critical and multifunctional nucleotide, adenosine 5'-triphosphate (ATP) is involved in many cellular metabolism and signal transduction processes. Monitoring the level and dynamics of ATP in living organisms contributes to better understanding of basic cellular functions. Fluorescent indicators are distinctly superior in detecting ATP in vivo due to their advantages of high sensitivity, good selectivity, fast response and flexible manipulation. The current indicators including small organic fluorescent chemosensors, genetically encoded fluorescent reporters, artificially designed aptamers conjugated with nanomaterials, and fluorescent nanosensors based on ATP-dependent luciferase have successfully achieved imaging of ATP in living cells or organisms, providing valuable insights into exploring related physiological actions. This article reviews the recent advances in the fluorescence analysis of ATP in vivo, describes their sensing mechanisms and characteristics, points out their applications in biological research, and offers prospects of the developments in the future. (C) 2016 Elsevier B.V. All rights reserved.; National Natural Science Foundation of China [21375004, 21575008]; Beijing Natural Science Foundation [2152014]; SCI(E); EI; ARTICLE; mpzhao@pku.edu.cn; 190-203; 80
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/437217]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Dong, Jiantong,Zhao, Meiping. In-vivo fluorescence imaging of adenosine 5 '-triphosphate[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2016.
APA	Dong, Jiantong,&Zhao, Meiping.(2016).In-vivo fluorescence imaging of adenosine 5 '-triphosphate.TRAC-TRENDS IN ANALYTICAL CHEMISTRY.
MLA	Dong, Jiantong,et al."In-vivo fluorescence imaging of adenosine 5 '-triphosphate".TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2016).