Computational design of proteins with novel structure and functions

doi:10.1088/1674-1056/25/1/018702

CORC > 北京大学 > 化学与分子工程学院

	Computational design of proteins with novel structure and functions
	Yang, Wei ; Lai, Lu-Hua
刊名	CHINESE PHYSICS B
	2016
关键词	computational protein design de novo protein design enzyme design protein-protein interaction ATOMIC-LEVEL ACCURACY HIGH-ACTIVITY MUTANTS DE-NOVO DESIGN ENERGY FUNCTIONS ENZYME DESIGN SIDE-CHAIN HUMAN BUTYRYLCHOLINESTERASE BINDING-PROTEINS 4-HELIX BUNDLE FORCE-FIELD
DOI	10.1088/1674-1056/25/1/018702
英文摘要	Computational design of proteins is a relatively new field, where scientists search the enormous sequence space for sequences that can fold into desired structure and perform desired functions. With the computational approach, proteins can be designed, for example, as regulators of biological processes, novel enzymes, or as biotherapeutics. These approaches not only provide valuable information for understanding of sequence-structure-function relations in proteins, but also hold promise for applications to protein engineering and biomedical research. In this review, we briefly introduce the rationale for computational protein design, then summarize the recent progress in this field, including de novo protein design, enzyme design, and design of protein-protein interactions. Challenges and future prospects of this field are also discussed.; National Basic Research Program of China [2015CB910300]; National High Technology Research and Development Program of China [2012AA020308]; National Natural Science Foundation of China [11021463]; SCI(E); EI; 中国科技核心期刊(ISTIC); REVIEW; lhlai@pku.edu.cn; 1; 310-316; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435607]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Yang, Wei,Lai, Lu-Hua. Computational design of proteins with novel structure and functions[J]. CHINESE PHYSICS B,2016.
APA	Yang, Wei,&Lai, Lu-Hua.(2016).Computational design of proteins with novel structure and functions.CHINESE PHYSICS B.
MLA	Yang, Wei,et al."Computational design of proteins with novel structure and functions".CHINESE PHYSICS B (2016).