Evaluation of synergistic enantioseparation systems with chiral   spirocyclic ionic liquids as additives by capillary electrophoresis

doi:10.1007/s00216-016-9356-8

CORC > 北京大学 > 化学与分子工程学院

	Evaluation of synergistic enantioseparation systems with chiral spirocyclic ionic liquids as additives by capillary electrophoresis
	Zhang, Yanjie ; Du, Shuaijing ; Feng, Zijie ; Du, Yingxiang ; Yan, Zhi
刊名	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
	2016
关键词	Chiral ionic liquids Capillary electrophoresis Enantiomeric separation Synergistic system Molecular modeling GAS-CHROMATOGRAPHY BETA-CYCLODEXTRIN STATIONARY PHASES SEPARATION SELECTOR ENANTIOSELECTIVITY DRUGS MEKC CD RECOGNITION
DOI	10.1007/s00216-016-9356-8
英文摘要	In recent years, chiral ionic liquids (CILs) have attracted more and more attention in the field of enantioseparation. In this study, two novel spirocyclic chiral ionic liquids, 1-butyl-3-methylimidazolium(T-4)-bis[(2S)-2-(hydroxy-kappa O)-3-methylbutanoato-kappa O]borate (BMIm(+)BLHvB(-)) and 1-butyl-3-methylimidazolium (T-4)-bis[(alpha S)-alpha-(hydroxy-kappa O)-4-methylbenzeneacetato-kappa O]borate (BMIm(+)BSMB(-)), were applied for the first time in capillary electrophoresis (CE) to establish synergistic systems for enantiomeric separation. Significantly improved separations of five tested analytes were observed in the CILs synergistic systems based on three beta-cyclodextrin derivatives (CD), compared with conventional single CD separation systems. Several principal parameters such as CILs concentration, cyclodextrin concentration, buffer pH, and applied voltage were systematically investigated with BMIm(+)BLHvB(-)/hydroxypropyl-beta-CD selected as a model system to optimize the enantioseparation. Molecular modeling was applied to further demonstrate the chiral recognition mechanism of the CILs/hydroxypropyl-beta-CD synergistic system, which showed a good agreement with the experimental results.; National Natural Science Foundation of China [81373378, 81072610]; Natural Science Foundation of Jiangsu Province [BK20150697]; Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); SCI(E); EI; PubMed; ARTICLE; du_yingxiang@126.com; 10; 2543-2555; 408
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434824]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Yanjie,Du, Shuaijing,Feng, Zijie,et al. Evaluation of synergistic enantioseparation systems with chiral spirocyclic ionic liquids as additives by capillary electrophoresis[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2016.
APA	Zhang, Yanjie,Du, Shuaijing,Feng, Zijie,Du, Yingxiang,&Yan, Zhi.(2016).Evaluation of synergistic enantioseparation systems with chiral spirocyclic ionic liquids as additives by capillary electrophoresis.ANALYTICAL AND BIOANALYTICAL CHEMISTRY.
MLA	Zhang, Yanjie,et al."Evaluation of synergistic enantioseparation systems with chiral spirocyclic ionic liquids as additives by capillary electrophoresis".ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2016).