Highly Catalytic Nanodots with Renal Clearance for Radiation Protection

doi:10.1021/acsnano.6b00321

CORC > 北京大学 > 化学与分子工程学院

	Highly Catalytic Nanodots with Renal Clearance for Radiation Protection
	Zhang, Xiao-Dong ; Zhang, Jinxuan ; Wang, Junying ; Yang, Jiang ; Chen, Jie ; Shen, Xiu ; Deng, Jiao ; Deng, Dehui ; Long, Wei ; Sun, Yuan-Ming ; Liu, Changlong ; Li, Meixian
刊名	ACS NANO
	2016
关键词	radiation radioprotectants MoS2 dots GUIDED PHOTOTHERMAL THERAPY CERIUM OXIDE NANOPARTICLES WALLED CARBON NANOTUBES IONIZING-RADIATION DRUG-DELIVERY NUCLEAR-POWER GOLD NANOPARTICLES CELLULAR-DAMAGE CANCER MOS2
DOI	10.1021/acsnano.6b00321
英文摘要	Ionizing radiation (gamma and X-ray) is widely used in industry and medicine, but it can also pose a significant hazardous effect on health and induce cancer, physical deformity, and even death, due to DNA damage and invasion of free radicals. There is therefore an urgent unmet demand in designing highly efficient radioprotectants with synergetic integration of effective renal clearance and low toxicity. In this study, we designed ultrasmall (sub-5 mn) highly catalytically active and cysteine-protected MoS2 dots as radioprotectants and investigated their application in protection against ionizing radiation. In vivo preclinical studies showed that the surviving fraction of MoS2-treated mice can appreciably increase to up to 79% when they were exposed to high-energy ionizing radiation. Furthermore, MoS2 dots can contribute in cleaning up the accumulated free radicals within the body, repairing DNA damage, and recovering all vital chemical and biochemical indicators, suggesting their unique role as free radical scavengers. MoS2 dots showed rapid and efficient urinary excretion with more than 80% injected dose eliminated from the body after 24 h due to their ultrasmall hydrodynamic size and did not cause any noticeable toxic responses up to 30 days.; National Natural Science Foundation of China [81471786, 21475003, 21275010]; Natural Science Foundation of Tianjin [13JCQNJC13500]; SCI(E); EI; PubMed; ARTICLE; xiaodongzhang@tju.edu.cn; lmwx@pku.edu.cn; 4; 4511-4519; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434360]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Xiao-Dong,Zhang, Jinxuan,Wang, Junying,et al. Highly Catalytic Nanodots with Renal Clearance for Radiation Protection[J]. ACS NANO,2016.
APA	Zhang, Xiao-Dong.,Zhang, Jinxuan.,Wang, Junying.,Yang, Jiang.,Chen, Jie.,...&Li, Meixian.(2016).Highly Catalytic Nanodots with Renal Clearance for Radiation Protection.ACS NANO.
MLA	Zhang, Xiao-Dong,et al."Highly Catalytic Nanodots with Renal Clearance for Radiation Protection".ACS NANO (2016).