Enhanced Anti-Tumor Efficacy through a Combination of Integrin alpha v   beta 6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition

doi:10.7150/thno.14792

CORC > 北京大学 > 化学与分子工程学院

	Enhanced Anti-Tumor Efficacy through a Combination of Integrin alpha v beta 6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition
	Gao, Liquan ; Zhang, Chenran ; Gao, Duo ; Liu, Hao ; Yu, Xinhe ; Lai, Jianhao ; Wang, Fan ; Lin, Jian ; Liu, Zhaofei
刊名	THERANOSTICS
	2016
关键词	Molecular imaging Photodynamic therapy Checkpoint inhibition Tumor metastasis Combination therapy NEAR-INFRARED PHOTOIMMUNOTHERAPY CANCER-IMMUNOTHERAPY ANTI-CTLA-4 THERAPY PANCREATIC-CANCER TUMOR-MODEL METASTASIS BLOCKADE MELANOMA ANTIBODY CELLS
DOI	10.7150/thno.14792
英文摘要	"Training" the host immune system to recognize and systemically eliminate residual tumor lesions and micrometastases is a promising strategy for cancer therapy. In this study, we investigated whether integrin alpha v beta 6-targeted photodynamic therapy (PDT) of tumors using a phthalocyanine dye-labeled probe (termed DSAB-HK) could trigger the host immune response, and whether PDT in combination with anti-PD-1 immune checkpoint inhibition could be used for the effective therapy of primary tumors and metastases. By near-infrared fluorescence imaging, DSAB-HK was demonstrated to specifically target either subcutaneous tumors in a 4T1 mouse breast cancer model or firefly luciferase stably transfected 4T1 (4T1-fLuc) lung metastatic tumors. Upon light irradiation, PDT by DSAB-HK significantly inhibited the growth of subcutaneous 4T1 tumors, and in addition promoted the maturation of dendritic cells and their production of cytokines, which subsequently stimulated the tumor recruitment of CD8(+) cytotoxic T lymphocytes. Furthermore, DSAB-HK PDT of the first tumor followed by PD-1 blockade markedly suppressed the growth of a second subcutaneous tumor, and also slowed the growth of 4T1-fLuc lung metastasis as demonstrated by serial bioluminescence imaging. Together, our results demonstrated the synergistic effect of tumor-targeted PDT and immune checkpoint inhibition for improving anti-tumor immunity and suppressing tumor growth/metastasis.; National Basic Research Program of China (973 program) [2013CB733802]; National Natural Science Foundation of China [81471712, 81222019, 81420108019]; Beijing Natural Science Foundation [7132131]; Beijing Nova Program [Z121107002512010]; SCI(E); PubMed; ARTICLE; liuzf@bjmu.edu.cn; 5; 627-637; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434343]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Gao, Liquan,Zhang, Chenran,Gao, Duo,et al. Enhanced Anti-Tumor Efficacy through a Combination of Integrin alpha v beta 6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition[J]. THERANOSTICS,2016.
APA	Gao, Liquan.,Zhang, Chenran.,Gao, Duo.,Liu, Hao.,Yu, Xinhe.,...&Liu, Zhaofei.(2016).Enhanced Anti-Tumor Efficacy through a Combination of Integrin alpha v beta 6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition.THERANOSTICS.
MLA	Gao, Liquan,et al."Enhanced Anti-Tumor Efficacy through a Combination of Integrin alpha v beta 6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition".THERANOSTICS (2016).