DNA Structural Correlation in Short and Long Ranges

doi:10.1021/acs.jpcb.5b06217

CORC > 北京大学 > 化学与分子工程学院

	DNA Structural Correlation in Short and Long Ranges
	Gu, Chan ; Zhang, Jun ; Yang, Y. Isaac ; Chen, Xi ; Ge, Hao ; Sun, Yujie ; Su, Xiaodong ; Yang, Lijiang ; Xie, Sunney ; Gao, Yi Qin
刊名	JOURNAL OF PHYSICAL CHEMISTRY B
	2015
关键词	MOLECULAR-DYNAMICS SIMULATIONS POLYMERASE BINDING-SITE NUCLEIC-ACID STRUCTURES AMBER FORCE-FIELD B-DNA NUCLEOTIDE-SEQUENCE ADENINE TRACT BASE-PAIRS PROTEIN RNA
DOI	10.1021/acs.jpcb.5b06217
英文摘要	Recent single-molecule measurements have revealed the DNA allostery in protein/DNA binding. MD simulations showed that this allosteric effect is associated with the deformation properties of DNA. In this study, we used MD simulations to further investigate the mechanism of DNA structural correlation, its dependence on DNA sequence, and the chemical modification of the bases. Besides a random sequence, poly d(AT) and poly d(GC) are also used as simpler model systems, which show the different bending and twisting flexibilities. The base-stacking interactions and the methyl group on the 5-carbon site of thymine causes local structures and flexibility to be very different for the two model systems, which further lead to obviously different tendencies of the conformational deformations, including the long-range allosteric effects.; National Program on Key Basic Research Project (973 Programs) [2012CB917304]; Natural Science Foundation of China [21233002, 91027044, 21125311, 21373016, 21373021]; SCI(E); EI; ARTICLE; xie@chemistry.harvard.edu; gaoyq@pku.edu.cn; 44; 13980-13990; 119
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/424579]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Gu, Chan,Zhang, Jun,Yang, Y. Isaac,et al. DNA Structural Correlation in Short and Long Ranges[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2015.
APA	Gu, Chan.,Zhang, Jun.,Yang, Y. Isaac.,Chen, Xi.,Ge, Hao.,...&Gao, Yi Qin.(2015).DNA Structural Correlation in Short and Long Ranges.JOURNAL OF PHYSICAL CHEMISTRY B.
MLA	Gu, Chan,et al."DNA Structural Correlation in Short and Long Ranges".JOURNAL OF PHYSICAL CHEMISTRY B (2015).