Rhodium(I)-Catalyzed Sequential C(sp)C(sp(3)) and C(sp(3))C(sp(3)) Bond   Formation through Migratory Carbene Insertion

doi:10.1002/anie.201503140

CORC > 北京大学 > 化学与分子工程学院

	Rhodium(I)-Catalyzed Sequential C(sp)C(sp(3)) and C(sp(3))C(sp(3)) Bond Formation through Migratory Carbene Insertion
	Xia, Ying ; Feng, Sheng ; Liu, Zhen ; Zhang, Yan ; Wang, Jianbo
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2015
关键词	carbenes cross-couplings diazo compounds migratory insertion quaternary carbon center NONACTIVATED ALKYL-HALIDES CROSS-COUPLING REACTIONS ALPHA-DIAZOCARBONYL COMPOUNDS C-C BOND GRIGNARD-REAGENTS SONOGASHIRA REACTIONS N-TOSYLHYDRAZONES C(SP(3))-H BONDS METAL CARBENE ALKYNYLATION
DOI	10.1002/anie.201503140
英文摘要	A Rh-I-catalyzed three-component reaction of tert-propargyl alcohol, diazoester, and alkyl halide has been developed. This reaction can be considered as a carbene-involving sequential alkyl and alkynyl coupling, in which C(sp)C(sp(3)) and C(sp(3))C(sp(3)) bonds are built successively on the carbenic carbon atom. The Rh-I-carbene migratory insertion of an alkynyl moiety and subsequent alkylation are proposed to account for the two separate CC bond formations. This reaction provides an efficient and tunable method for the construction of all-carbon quaternary center.; National Basic Research Program of China (973 Program) [2012CB821600]; NSFC [21472004, 21332002]; SCI(E); EI; PubMed; ARTICLE; wangjb@pku.edu.cn; 27; 7891-7894; 54
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/419122]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Xia, Ying,Feng, Sheng,Liu, Zhen,et al. Rhodium(I)-Catalyzed Sequential C(sp)C(sp(3)) and C(sp(3))C(sp(3)) Bond Formation through Migratory Carbene Insertion[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015.
APA	Xia, Ying,Feng, Sheng,Liu, Zhen,Zhang, Yan,&Wang, Jianbo.(2015).Rhodium(I)-Catalyzed Sequential C(sp)C(sp(3)) and C(sp(3))C(sp(3)) Bond Formation through Migratory Carbene Insertion.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Xia, Ying,et al."Rhodium(I)-Catalyzed Sequential C(sp)C(sp(3)) and C(sp(3))C(sp(3)) Bond Formation through Migratory Carbene Insertion".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015).