Silver(I)-Catalyzed N-Trifluoroethylation of Anilines and   O-Trifluoroethylation of Amides with 2,2,2-Trifluorodiazoethane

doi:10.1002/anie.201507219

CORC > 北京大学 > 化学与分子工程学院

	Silver(I)-Catalyzed N-Trifluoroethylation of Anilines and O-Trifluoroethylation of Amides with 2,2,2-Trifluorodiazoethane
	Luo, Haiqing ; Wu, Guojiao ; Zhang, Yan ; Wang, Jianbo
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2015
关键词	amides aniline carbenes diazo compounds silver HIGHLY ENANTIOSELECTIVE INSERTION ALPHA-AMINO-ACIDS H BONDS DIAZO-COMPOUNDS TRIFLUOROMETHYLATION COMPLEXES COPPER ALKYNES ESTERS CYCLOADDITION
DOI	10.1002/anie.201507219
英文摘要	A straightforward N-trifluoroethylation of anilines has been developed based on silver-catalyzed N - H insertions with 2,2,2-trifluorodiazoethane (CF3CHN2). Mechanistically, the reaction is proposed to involve migratory insertion of a silver carbene as the key step. In contrast, when amides are employed as the substrates under similar reaction conditions, O-trifluoroethylation occurs to afford trifluoroethyl imidates.; National Basic Research Program of China (973 Program) [2012CB821600]; NSFC [21472004, 21332002]; SCI(E); EI; PubMed; ARTICLE; wangjb@pku.edu.cn; 48; 14503-14507; 54
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418142]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Luo, Haiqing,Wu, Guojiao,Zhang, Yan,et al. Silver(I)-Catalyzed N-Trifluoroethylation of Anilines and O-Trifluoroethylation of Amides with 2,2,2-Trifluorodiazoethane[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015.
APA	Luo, Haiqing,Wu, Guojiao,Zhang, Yan,&Wang, Jianbo.(2015).Silver(I)-Catalyzed N-Trifluoroethylation of Anilines and O-Trifluoroethylation of Amides with 2,2,2-Trifluorodiazoethane.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Luo, Haiqing,et al."Silver(I)-Catalyzed N-Trifluoroethylation of Anilines and O-Trifluoroethylation of Amides with 2,2,2-Trifluorodiazoethane".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015).